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. 1985 Mar;53(3):265–268. doi: 10.1136/hrt.53.3.265

Coronary artery disease and haemostatic variables in heterozygous familial hypercholesterolaemia.

D D Sugrue, I Trayner, G R Thompson, V J Vere, J Dimeson, Y Stirling, T W Meade
PMCID: PMC481754  PMID: 3970784

Abstract

Haemostatic variables were measured in 61 patients with heterozygous familial hypercholesterolaemia, 32 of whom had evidence of coronary heart disease. Age adjusted mean concentrations of plasma fibrinogen and factor VIII were significantly higher in these patients than in the 29 patients without coronary heart disease, but there were no significant differences in serum lipid concentrations between the two groups. Comparisons in 30 patients taking and not taking lipid lowering drugs showed lower values for low density lipoprotein cholesterol, high density lipoprotein cholesterol and antithrombin III, and a higher high density lipoprotein ratio while receiving treatment. The results suggest that hypercoagulability may play a role in the pathogenesis of coronary heart disease in patients with familial hypercholesterolaemia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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