Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1985 Apr;53(4):400–404. doi: 10.1136/hrt.53.4.400

Cellular immunity in congestive cardiomyopathy. Hypersensitivity to cardiac antigens.

P J Lowry, R A Thompson, W A Littler
PMCID: PMC481780  PMID: 3885980

Abstract

The presence of type IV hypersensitivity to cardiac antigens in 26 patients with congestive cardiomyopathy was sought by two in vitro techniques. Neither test showed a significant group abnormality, but 10 patients did have hypersensitivity to heart antigen, in particular to congestive cardiomyopathic heart antigen. These patients were characterised by worse haemodynamic data and a more rapid and malignant course of the disease than in the rest of the group.

Full text

PDF
400

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. L., Fowles R. E., Bieber C. P., Stinson E. B. Idiopathic cardiomyopathy, age, and suppressor-cell dysfunction as risk determinants of lymphoma after cardiac transplantation. Lancet. 1978 Dec 2;2(8101):1174–1177. doi: 10.1016/s0140-6736(78)92156-6. [DOI] [PubMed] [Google Scholar]
  2. Cambridge G., MacArthur C. G., Waterson A. P., Goodwin J. F., Oakley C. M. Antibodies to Coxsackie B viruses in congestive cardiomyopathy. Br Heart J. 1979 Jun;41(6):692–696. doi: 10.1136/hrt.41.6.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DAUGHADAY W. H., LOWRY O. H., ROSEBROUGH N. J., FIELDS W. S. Determination of cerebrospinal fluid protein with the Folin phenol reagent. J Lab Clin Med. 1952 Apr;39(4):663–665. [PubMed] [Google Scholar]
  4. Das S. K., Stein L. D., Thebert P. J., Reynolds R. T., Cassidy J. T. Inhibition of leucocyte migration by stimulated mononuclear cell supernatants from patients with ischaemic heart disease. Br Heart J. 1983 Apr;49(4):381–387. doi: 10.1136/hrt.49.4.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dumonde D. C., Maini R. N. The clinical significance of mediators of cellular immunity. Clin Allergy. 1971 Mar;1(1):123–139. doi: 10.1111/j.1365-2222.1971.tb02453.x. [DOI] [PubMed] [Google Scholar]
  6. Federlin K., Maini R. N., Russell A. S., Dumonde D. C. A micro-method for peripheral leucocyte migration in tuberculin sensitivity. J Clin Pathol. 1971 Sep;24(6):533–536. doi: 10.1136/jcp.24.6.533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goodwin J. F., Oakley C. M. The cardiomyopathies. Br Heart J. 1972 Jun;34(6):545–552. doi: 10.1136/hrt.34.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Goodwin J. F. The frontiers of cardiomyopathy. Br Heart J. 1982 Jul;48(1):1–18. doi: 10.1136/hrt.48.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Górski A. J. Superiority of corpuscular BCG to soluble PPD antigen in the leucocyte migration assay. Clin Exp Immunol. 1974 Sep;18(1):149–153. [PMC free article] [PubMed] [Google Scholar]
  10. Kawai C. Idiopathic cardiomyopathy. A study on the infectious-immune theory as a cause of the disease. Jpn Circ J. 1971 Jul;35(7):765–770. doi: 10.1253/jcj.35.765. [DOI] [PubMed] [Google Scholar]
  11. Lowry P. J., Thompson R. A., Littler W. A. Cellular immunity in congestive cardiomyopathy. The normal cellular immune response. Br Heart J. 1985 Apr;53(4):394–399. doi: 10.1136/hrt.53.4.394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  13. Murray A. B., Ferguson A. C. A comparison of spirometric measurements in allergen bronchial challenge testing. Clin Allergy. 1981 Jan;11(1):87–93. doi: 10.1111/j.1365-2222.1981.tb01570.x. [DOI] [PubMed] [Google Scholar]
  14. Ortiz-Ortiz L., Zamacona G., Garmilla C., Arellano M. T. Migration inhibition test in leukocytes from patients allergic to penicillin. J Immunol. 1974 Sep;113(3):993–997. [PubMed] [Google Scholar]
  15. Sharma R. K., Ahuja R. C., Tandon O. P., Chaturvedi U. C. Leucocyte migration inhibition test in cases of ischaemic heart disease. Br Heart J. 1978 May;40(5):541–546. doi: 10.1136/hrt.40.5.541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Trueman T., Thompson R. A., Cummins P., Littler W. A. Heart antibodies in cardiomyopathies. Br Heart J. 1981 Sep;46(3):296–301. doi: 10.1136/hrt.46.3.296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wilson F. M., Miranda Q. R., Chason J. L., Lerner A. M. Residual pathologic changes following murine coxsackie A and B myocarditis. Am J Pathol. 1969 May;55(2):253–265. [PMC free article] [PubMed] [Google Scholar]
  18. Woodruff J. F., Woodruff J. J. Involvement of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease. J Immunol. 1974 Dec;113(6):1726–1734. [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES