Abstract
In 100 children with suspected left to right shunts the ratio of pulmonary to systemic flow was measured both by oximetry and first pass radionuclide angiography. The pulmonary time activity curve from the radionuclide study was analysed by the method of gamma variate fits. There was strong correlation between the two techniques; weaker correlation was found when the shunt was at atrial rather than ventricular level. This difference can be explained only by problems with the oximetric rather than the radionuclide technique. Although there are important limitations to the radionuclide method, it is the more precise and less invasive of the two and is to be preferred when the accurate measurement of left to right shunts is required.
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Selected References
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- Alderson P. O., Douglass K. H., Mendenhall K. G., Guadiani V. A., Watson D. C., Links J. M., Wagner H. N., Jr Deconvolution analysis in radionuclide quantitation of left-to-right cardiac shunts. J Nucl Med. 1979 Jun;20(6):502–506. [PubMed] [Google Scholar]
- Alderson P. O., Jost R. G., Strauss A. W., Boonvisut S., Markham J. Radionuclide angiocardiography. Improved diagnosis and quantitation of left-to-right shunts using area ratio techniques in children. Circulation. 1975 Jun;51(6):1136–1143. doi: 10.1161/01.cir.51.6.1136. [DOI] [PubMed] [Google Scholar]
- Anderson P. A., Jones R. H., Sabiston D. C., Jr Quantitation of left-to-right cardiac shunts with radionuclide angiography. Circulation. 1974 Mar;49(3):512–516. doi: 10.1161/01.cir.49.3.512. [DOI] [PubMed] [Google Scholar]
- Askenazi J., Ahnberg D. S., Korngold E., LaFarge C. G., Maltz D. L., Treves S. Quantitative radionuclide angiocardiography: detection and quantitation of left to right shunts. Am J Cardiol. 1976 Mar 4;37(3):382–387. doi: 10.1016/0002-9149(76)90287-3. [DOI] [PubMed] [Google Scholar]
- BARRATT-BOYES B. G., WOOD E. H. The oxygen saturation of blood in the venae cavae, right-heart chambers, and pulmonary vessels of healthy subjects. J Lab Clin Med. 1957 Jul;50(1):93–106. [PubMed] [Google Scholar]
- Ginzton L. E., French W., Mena I. Combined contrast echocardiographic and radionuclide diagnosis of atrial septal defect: accuracy of the technique and analysis of erroneous diagnoses. Am J Cardiol. 1984 Jun 1;53(11):1639–1642. doi: 10.1016/0002-9149(84)90593-9. [DOI] [PubMed] [Google Scholar]
- HOLLING H. E., MACDONALD I., O'HALLORAN J. A., VENNER A. Reliability of a spectrophotometric method of estimating blood oxygen. J Appl Physiol. 1955 Nov;8(3):249–254. doi: 10.1152/jappl.1955.8.3.249. [DOI] [PubMed] [Google Scholar]
- Hurwitz R. A., Treves S., Keane J. F., Girod D. A., Caldwell R. L. Current value of radionuclide angiocardiography for shunt quantification and management in patients with secundum atrial septal defect. Am Heart J. 1982 Mar;103(3):421–425. doi: 10.1016/0002-8703(82)90283-6. [DOI] [PubMed] [Google Scholar]
- McIlveen B. M., Murray I. P., Giles R. W., Molk G. H., Scarf C. M., McCredie R. M. Clinical application of radionuclide quantitation of left to right cardiac shunts in children. Am J Cardiol. 1981 Jun;47(6):1273–1278. doi: 10.1016/0002-9149(81)90258-7. [DOI] [PubMed] [Google Scholar]
- Miller H. C., Brown D. J., Miller G. A. Comparison of formulae used to estimate oxygen saturation of mixed venous blood from caval samples. Br Heart J. 1974 May;36(5):446–451. doi: 10.1136/hrt.36.5.446. [DOI] [PMC free article] [PubMed] [Google Scholar]