Fig. 2.

Role of miR-188-5p in regulating the involvement of BMCs in the pathogenesis of choroidal neovascularization. We observed the relationship between miR-188-5p and MMP-2/13 in MSCs and demonstrated that overexpression of miR-188-5p attenuated the development of CNV as well as the effect of BMCs (unpublished data). These findings are consistent with the hypothesis that miR-188-5p may affect the proliferation, migration and apoptosis of vascular cells and fibrosis of CNV via regulating the MMP-2 and -13 expressions in BMCs, especially MSCs. BMCs bone marrow-derived cells, MSCs mesenchymal stem cells, MMP2/13 matrix metalloproteinase-2/13, VEC vascular endothelial cells