Abstract
After an acute myocardial infarction, there is an apparent acute fall in leucocyte ascorbic acid associated with an acute rise in white blood cells and serum cortisol. The apparent fall in leucocyte ascorbic acid is the result of the granulocytosis which occurs after the infarction. Estimations of ascorbic acid disclose that the granulocyte contains approximately half the ascorbic acid of the lymphocyte. When the granulocytosis subsides, the new population of white blood cells is depleted of ascorbic acid for at least 56 days, reflecting tissue desaturation which can be corrected by ascorbic acid supplements. Tissue desaturation is also reflected in subnormal serum ascorbic acid levels which persist also unless ascorbic acid supplements are given. Observations on normal subjects given infusions of tetracosactrin (Synacthen) show that adrenal stimulation can produce a similar rise in white blood cells and an apparent fall in leucocyte ascorbic acid concentration with the exception that the serum ascorbic acid remains unaltered. Therefore, while adrenal stimulation can mimic 'stress' with regard to the changes in the white blood cells, tissue depletion of ascorbic acid as reflected in the white blood cells and serum after a myocardial infarction requires a focus of damaged tissue.
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Selected References
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- Bailey R. R., Abernethy M. H., Beaven D. W. Adrenocartical response to the stress of an acute myocardial infarction. Lancet. 1967 May 6;1(7497):970–973. doi: 10.1016/s0140-6736(67)92356-2. [DOI] [PubMed] [Google Scholar]
- Boddy K., Hume R., King P. C., Weyers E., Rowan T. Total body, plasma and erythrocyte potassium and leucocyte ascorbic acid in 'ultra-fit' subjects. Clin Sci Mol Med. 1974 Apr;46(4):449–456. doi: 10.1042/cs0460449. [DOI] [PubMed] [Google Scholar]
- DENSON K. W., BOWERS E. F. The determination of ascorbic acid in white blood cells. A comparison of W.B.C. ascorbic acid and phenolic acid excretion in elderly patients. Clin Sci. 1961 Oct;21:157–162. [PubMed] [Google Scholar]
- Hume R., Weyers E. Changes in leucocyte ascorbic acid during the common cold. Scott Med J. 1973 Jan;18(1):3–7. doi: 10.1177/003693307301800102. [DOI] [PubMed] [Google Scholar]
- Hume R., Weyers E., Rowan T., Reid D. S., Hillis W. S. Leucocyte ascorbic acid levels after acute myocardial infarction. Br Heart J. 1972 Mar;34(3):238–243. doi: 10.1136/hrt.34.3.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]