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. 1992 Jan 1;89(1):172–176. doi: 10.1073/pnas.89.1.172

Peripherin: an islet antigen that is cross-reactive with nonobese diabetic mouse class II gene products.

C Boitard 1, M C Villa 1, C Becourt 1, H P Gia 1, C Huc 1, P Sempe 1, M M Portier 1, J F Bach 1
PMCID: PMC48198  PMID: 1729686

Abstract

The nonobese diabetic (NOD) mouse, in which major histocompatibility complex genes may be involved in the susceptibility to diabetes, has been developed as a model of autoimmune diabetes. The NOD mouse expresses I-A-encoded class II major histocompatibility complex antigens, which differ from those of other mouse haplotypes by the presence of a serine at position 57 of the A beta chain. Identifying islet autoantigens may help elucidate the role of class II antigens in the activation of autoreactive T cells and, thus, in the development of diabetes. We have detected autoantibodies directed against a 58-kDa islet cell antigen in NOD mice but not in other strains, including lupus-prone mice. Apart from insulin-secreting cells, the 58-kDa antigen was only found to be expressed by neuroblastoma cells and was identified as peripherin, an intermediate filament protein previously characterized in well-defined neuronal populations. This autoantigen cross-reacted with I-Anod class II antigens, suggesting that it may contribute to defective self-tolerance of islet beta cells in the NOD mouse.

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Selected References

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