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. 1978 Mar;40(3):215–220. doi: 10.1136/hrt.40.3.215

Histopathology of the ductus arteriosus after prostaglandin E1 administration in ductus dependent cardiac anomalies.

A C Gittenberger-de Groot, A J Moulaert, E Harinck, A E Becker
PMCID: PMC481984  PMID: 637973

Abstract

The histology of the ductus arteriosus was studied after prostaglandin E1 (PGE1) administration in 4 infants with ductus dependent cardiac malformations. Pronounced pathological changes were found in each instance. The changes consisted of oedema of the media with separation of medial components by clear spaces, pathological interruptions of the internal elastic lamina, and intimal lacerations, some of which extended into the media. The findings suggest that PGE1 administration has a profound weakening effect on the structure of the wall of the ductus arteriosus, rendering the vessel prone to laceration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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