Abstract
99mTc-Imidodiphosphonate was investigated as a new myocardial infarct imaging agent. In the acute phase, 50 patients admitted to the coronary care unit were serially scanned over a period of 7 days. A mobile gamma camera linked on line to a remote data processor was used. Because of higher uptake in infarcted myocardium and faster blood clearance, superior images than those recorded with 99mTc-pyrophosphate were obtained. Its ease of preparation, low cost, and favourable dosimetry (because of its label with conventional 99mTc) transforms this agent into the present radiopharmaceutical of choice for acute infarct imaging in particular if sizing and follow-up is intended versus time and type of treatment. In this series, no false positive cases were seen. The sensitivity of the method in the detection of full thickness myocardial infarction was 95%. It dropped to 70% in the detection of subendocardial infarction. However, some of these apparent false negative cases may reflect severe ischaemia without infarction. It is postulated that this discrimination may not always be realistic.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ell P. J., Langford R., Pearce P., Lui D., Elliott A. T., Woolf N., Williams E. S. 99mTc-imidodiphosphonate: a superior radio-pharmaceutical for in vivo positive myocardial infarct imaging. I: Experimental data. Br Heart J. 1978 Mar;40(3):226–233. doi: 10.1136/hrt.40.3.226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ell P. J. Scan analysis in myocardial infarction. Nuklearmedizin. 1976 Aug;15(4):157–159. [PubMed] [Google Scholar]
- Ell P. J. The clinical role of skeletal scanning. Ann R Coll Surg Engl. 1975 Dec;57(6):313–325. [PMC free article] [PubMed] [Google Scholar]
- Grossman Z. D., Foster A. B., McAfee J. G., Richardson R., Subramanian G., Markarian B., Gagne G., Bassano D. Myocardial uptake (rabbit) of six 99mTc-tagged pharmaceuticals and 85Sr after vasopressin-induced necrosis. J Nucl Med. 1977 Jan;18(1):51–56. [PubMed] [Google Scholar]
- McConahay D. R., McCallister B. D., Hallermann F. J., Smith R. E. Comparative quantitative analysis of the electrocardiogram and the vectorcardiogram. Correlations with the coronary arteriogram. Circulation. 1970 Aug;42(2):245–259. doi: 10.1161/01.cir.42.2.245. [DOI] [PubMed] [Google Scholar]
- PAPP C. Acute cardiac infarction without pain. Br Heart J. 1952 Apr;14(2):250–260. doi: 10.1136/hrt.14.2.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parkey R. W., Bonte F. J., Buja L. M., Stokely E. M., Willerson J. T. Myocardial infarct imaging with technetium-99m phosphates. Semin Nucl Med. 1977 Jan;7(1):15–28. doi: 10.1016/s0001-2998(77)80004-4. [DOI] [PubMed] [Google Scholar]
- SAVRANOGLU N., BOUCEK R. J., CASTEN G. G. The extent of reversibility of myocardial ischemia in dogs. Am Heart J. 1959 Nov;58:726–731. doi: 10.1016/0002-8703(59)90231-5. [DOI] [PubMed] [Google Scholar]
- Sobel B. E., Shell W. E. Serum enzyme determinations in the diagnosis and assessment of myocardial infarction. Circulation. 1972 Feb;45(2):471–482. doi: 10.1161/01.cir.45.2.471. [DOI] [PubMed] [Google Scholar]