Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1979 Apr;41(4):477–480. doi: 10.1136/hrt.41.4.477

Blood volume in angina pectoris.

H Aström, A Holmgren, B Jonsson
PMCID: PMC482056  PMID: 157145

Abstract

Blood volume was measured in 60 consecutive male patients with disabling angina pectoris undergoing preoperative investigation for coronary bypass surgery. Of these patients, 58 had a lower blood volume than predicted. There was a decrease in blood volume of 21% (1.3 litres) from the predicted normal value (P less than 0.001). Seventeen per cent of the patients were on diuretics, 30% were on digitalis, and 48% were on beta-blocking drugs at the time of the study. There was no correlation between this medical treatment and the deviation in blood volume. In patients without signs of myocardial insufficiency the decrease in blood volume was most prominent, while in those with an enlarged heart and a raised left ventricular preload (at rest) the deviation was less.

Full text

PDF
477

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett E. D., Brooks N. J., Keddie J., Lis Y., Wilson A. Increased renal function in patients with acute left ventricular failure: a possible homeostatic mechanism. Clin Sci Mol Med. 1977 Jan;52(1):43–50. doi: 10.1042/cs0520043. [DOI] [PubMed] [Google Scholar]
  2. Goetz K. L., Bond G. C., Bloxham D. D. Atrial receptors and renal function. Physiol Rev. 1975 Apr;55(2):157–205. doi: 10.1152/physrev.1975.55.2.157. [DOI] [PubMed] [Google Scholar]
  3. Greenberg T. T., Richmond W. H., Stocking R. A., Gupta P. D., Meehan J. P., Henry J. P. Impaired atrial receptor responses in dogs with heart failure due to tricuspid insufficiency and pulmonary artery stenosis. Circ Res. 1973 Apr;32(4):424–433. doi: 10.1161/01.res.32.4.424. [DOI] [PubMed] [Google Scholar]
  4. Gábor G., Istvanffy M., Halmagyi M. Increase of intravascular blood volume in Ischaemic heart disease. Cardiovasc Res. 1976 Mar;10(2):153–159. doi: 10.1093/cvr/10.2.153. [DOI] [PubMed] [Google Scholar]
  5. HOLMGREN A., JONSSON B., LINDERHOLM H., SJOSTRAND T., STROM G. Fysisk arbetsförmâga vid mitralisvitium och dess relation till hjärtvolym, total hämoglobinmängd och slagvolym. Nord Med. 1957 Nov 7;58(45):1714–1719. [PubMed] [Google Scholar]
  6. HOLMGREN A., MOSSFELDT F., SJOSTRAND T., STROM G. Effect of training on work capacity, total hemoglobin, blood volume, heart volume and pulse rate in recumbent and upright positions. Acta Physiol Scand. 1960 Sep 30;50:72–83. doi: 10.1111/j.1748-1716.1960.tb02075.x. [DOI] [PubMed] [Google Scholar]
  7. Hesse B., Bollerup A. C., Olesen K. H. The influence of beta-blocking agents on plasma volume and extracellular volume in ischaemic heart disease. Scand J Clin Lab Invest. 1974 Nov;34(3):215–217. [PubMed] [Google Scholar]
  8. Holmgren A. Total hemoglobin, techniques, normal values, relation to fitness values in heart patients. Mal Cardiovasc. 1969;10(1):341–357. [PubMed] [Google Scholar]
  9. Jonsson B., Olsson A. G., Orö L. Effects of alprenolol on central hemodynamics and exercise tolerance in patients with angina pectoris. Cardiology. 1973;58(3):152–161. [PubMed] [Google Scholar]
  10. Lecerof H. Influence of body position on exercise tolerance, heart rate, blood pressure, and respiration rate in coronary insufficiency. Br Heart J. 1971 Jan;33(1):78–83. doi: 10.1136/hrt.33.1.78. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mason D. T., Braunwald E. The effects of nitroglycerin and amyl nitrite on arteriolar and venous tone in the human forearm. Circulation. 1965 Nov;32(5):755–766. doi: 10.1161/01.cir.32.5.755. [DOI] [PubMed] [Google Scholar]
  12. Oberg B., White S. Circulatory effects of interruption and stimulation of cardiac vagal afferents. Acta Physiol Scand. 1970 Nov;80(3):383–394. doi: 10.1111/j.1748-1716.1970.tb04802.x. [DOI] [PubMed] [Google Scholar]
  13. Parker J. O., Case R. B., Khaja F., Ledwich J. R., Armstrong P. W. The influence of changes in blood volume on angina pectoris. A study of the effect of phlebotomy. Circulation. 1970 Apr;41(4):593–604. doi: 10.1161/01.cir.41.4.593. [DOI] [PubMed] [Google Scholar]
  14. Sederberg-Olsen P., Ibsen H. Plasma volume and extracellular fluid volume during long-term treatment with propranolol in essential hypertension. Clin Sci. 1972 Aug;43(2):165–170. doi: 10.1042/cs0430165. [DOI] [PubMed] [Google Scholar]
  15. Sleight P., Widdicombe J. G. Action potentials in fibres from receptors in the epicardium and myocardium of the dog's left ventricle. J Physiol. 1965 Nov;181(2):235–258. doi: 10.1113/jphysiol.1965.sp007758. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Tarazi R. C., Frohlich E. D., Dustan H. P. Plasma volume changes with long-term beta-adrenergic blockade. Am Heart J. 1971 Dec;82(6):770–776. doi: 10.1016/0002-8703(71)90198-0. [DOI] [PubMed] [Google Scholar]
  17. WILLIAMS J. A., FINE J. Measurement of blood volume with a new apparatus. N Engl J Med. 1961 Apr 27;264:842–848. doi: 10.1056/NEJM196104272641702. [DOI] [PubMed] [Google Scholar]
  18. Williams J. F., Jr, Glick G., Braunwald E. Studies on cardiac dimensions in intact unanesthetized man. V. Effects of nitroglycerin. Circulation. 1965 Nov;32(5):767–771. doi: 10.1161/01.cir.32.5.767. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES