Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1980 Jan;43(1):88–91. doi: 10.1136/hrt.43.1.88

Beneficial effects of intravenous glyceryl trinitrate in a case of Prinzmetal angina.

E Antman, S Gunther, W Barry
PMCID: PMC482246  PMID: 6766728

Abstract

A case is described of the successful use of intravenous glyceryl trinitrate in controlling ischaemia-induced high-grade ventricular ectopic activity occurring in a patient during a Prinzmetal angina attack. The intravenous form of glyceryl trinitrate is probably more effective than the sublingual form in controlling arrhythmias arising during acute ischaemic episodes because of prompt delivery of the drug to the coronary circulation where vasodilation occurs. In addition,the ability to control the quantity and rate of drug delivery with an intravenous infusion offers distinct advantages in cases of coronary spasm occurring during situations such as coronary arteriography where it can be administered with careful electrocardiographic and haemodynamic monitoring.

Full text

PDF
88

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bigger J. T., Jr, Dresdale F. J., Heissenbuttel R. H., Weld F. M., Wit A. L. Ventricular arrhythmias in ischemic heart disease: mechanism, prevalence, significance, and management. Prog Cardiovasc Dis. 1977 Jan-Feb;19(4):255–300. doi: 10.1016/0033-0620(77)90005-6. [DOI] [PubMed] [Google Scholar]
  2. Chiariello M., Gold H. K., Leinbach R. C., Davis M. A., Maroko P. R. Comparison between the effects of nitroprusside and nitroglycerin on ischemic injury during acute myocardial infarction. Circulation. 1976 Nov;54(5):766–773. doi: 10.1161/01.cir.54.5.766. [DOI] [PubMed] [Google Scholar]
  3. Endo M., Hirosawa K., Kaneko N., Hase K., Inoue Y. Prinzmetal's variant angina. Coronary arteriogram and left ventriculogram during angina attack induced by methacholine. N Engl J Med. 1976 Jan 29;294(5):252–255. doi: 10.1056/NEJM197601292940505. [DOI] [PubMed] [Google Scholar]
  4. Epstein S. E., Kent K. M., Goldstein R. E., Borer J. S., Redwood D. R. Reduction of ischemic injury by nitroglycerin during acute myocardial infarction. N Engl J Med. 1975 Jan 2;292(1):29–35. doi: 10.1056/NEJM197501022920107. [DOI] [PubMed] [Google Scholar]
  5. Hope R. R., Williams D. O., el-Sherif N., Lazzara R., Scherlag B. J. The efficacy of antiarrhythmic agents during acute myocardial ischemia and the role of heart rate. Circulation. 1974 Sep;50(3):507–514. doi: 10.1161/01.cir.50.3.507. [DOI] [PubMed] [Google Scholar]
  6. Kupersmith J., Antman E. M., Hoffman B. F. In vivo electrophysiological effects of lidocaine in canine acute myocardial infarction. Circ Res. 1975 Jan;36(1):84–91. doi: 10.1161/01.res.36.1.84. [DOI] [PubMed] [Google Scholar]
  7. MacAlpin R. Editorial: Provoking variant angina. N Engl J Med. 1976 Jan 29;294(5):277–278. doi: 10.1056/NEJM197601292940513. [DOI] [PubMed] [Google Scholar]
  8. Maseri A., L'Abbate A., Baroldi G., Chierchia S., Marzilli M., Ballestra A. M., Severi S., Parodi O., Biagini A., Distante A. Coronary vasospasm as a possible cause of myocardial infarction. A conclusion derived from the study of "preinfarction" angina. N Engl J Med. 1978 Dec 7;299(23):1271–1277. doi: 10.1056/NEJM197812072992303. [DOI] [PubMed] [Google Scholar]
  9. Oliva P. B., Potts D. E., Pluss R. G. Coronary arterial spasm in Prinzmetal angina. Documentation by coronary arteriography. N Engl J Med. 1973 Apr 12;288(15):745–751. doi: 10.1056/NEJM197304122881501. [DOI] [PubMed] [Google Scholar]
  10. PRINZMETAL M., KENNAMER R., MERLISS R., WADA T., BOR N. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med. 1959 Sep;27:375–388. doi: 10.1016/0002-9343(59)90003-8. [DOI] [PubMed] [Google Scholar]
  11. Schroeder J. S., Bolen J. L., Quint R. A., Clark D. A., Hayden W. G., Higgins C. B., Wexler L. Provocation of coronary spasm with ergonovine maleate. New test with results in 57 patients undergoing coronary arteriography. Am J Cardiol. 1977 Oct;40(4):487–491. doi: 10.1016/0002-9149(77)90060-1. [DOI] [PubMed] [Google Scholar]
  12. The early phase of acute myocardial infarction: pharmacologic aspects of therapy. Ann Intern Med. 1973 Jun;78(6):918–936. doi: 10.7326/0003-4819-78-6-918. [DOI] [PubMed] [Google Scholar]
  13. Yasue H., Touyama M., Shimamoto M., Kato H., Tanaka S. Role of autonomic nervous system in the pathogenesis of Prinzmetal's variant form of angina. Circulation. 1974 Sep;50(3):534–539. doi: 10.1161/01.cir.50.3.534. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES