Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1980 Feb;43(2):134–137. doi: 10.1136/hrt.43.2.134

Haemodynamic effects of prenalterol in patients with coronary heart disease.

I Hutton, R G Murray, R N Boyes, A P Rae, W S Hillis
PMCID: PMC482252  PMID: 6102468

Abstract

The haemodynamic effects of prenalterol, a new selective beta-1 adrenoreceptor agonist, have been studied in patients with coronary heart disease. The drug was administered intravenously in a dosage of 0.5 to 2.5 micrograms/kg body weight to 20 patients undergoing coronary angiography and to 10 patients with a recent myocardial infarction, who had clinical evidence of left ventricular dysfunction. Left ventricular performance was enhanced in both groups of patients--left ventricular dP/dt (max) increased by 33 per cent and the systolic time intervals, pre-ejection period, and the ratio of pre-ejection period and left ventricular ejection shortened by 28 and 21 per cent, respectively. Cardiac output and stroke volume increased with no change in heart rate nor in left ventricular filling pressure. These results indicate that prenalterol enhances the contractile state of the myocardium without altering heart rate, and suggest that prenalterol could be of value in the management of patients with coronary heart disease, who have impaired left ventricular function.

Full text

PDF
134

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Carlsson E., Dahlöf C. G., Hedberg A., Persson H., Tångstrand B. Differentiation of cardiac chronotropic and inotropic effects of beta-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol. 1977 Nov;300(2):101–105. doi: 10.1007/BF00505039. [DOI] [PubMed] [Google Scholar]
  2. Furnival C. M., Linden R. J., Snow H. M. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure. J Physiol. 1970 Dec;211(2):359–387. doi: 10.1113/jphysiol.1970.sp009283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Garrard C. L., Jr, Weissler A. M., Dodge H. T. The relationship of alterations in systolic time intervals to ejection fraction in patients with cardiac disease. Circulation. 1970 Sep;42(3):455–462. doi: 10.1161/01.cir.42.3.455. [DOI] [PubMed] [Google Scholar]
  4. Gillespie T. A., Ambos H. D., Sobel B. E., Roberts R. Effects of dobutamine in patients with acute myocardial infarction. Am J Cardiol. 1977 Apr;39(4):588–594. doi: 10.1016/s0002-9149(77)80170-7. [DOI] [PubMed] [Google Scholar]
  5. Hutton I., Hillis W. S., Langhan C. E., Conely J. M., Lawrie T. D. Cardiovascular effects of a new inotropic agent, U. K. 14275, in patients with coronary heart disease. Br J Clin Pharmacol. 1977 Oct;4(5):513–517. doi: 10.1111/j.1365-2125.1977.tb00778.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Johnsson G., Jordö L., Lundborg P., Rönn O., Welin-Fogelberg I., Wikstrand J. Haemodynamic and tolerance studies in man of a new, orally active, selective beta1-adrenoceptor agonist H 80/62. Eur J Clin Pharmacol. 1978 May 31;13(3):163–170. doi: 10.1007/BF00609978. [DOI] [PubMed] [Google Scholar]
  7. Kersting F., Follath F., Moulds R., Mucklow J., McCloy R., Sheares J., Dollery C. A comparison of cardiovascular effects of dobutamine and isoprenaline after open heart surgery. Br Heart J. 1976 Jun;38(6):622–626. doi: 10.1136/hrt.38.6.622. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Talley R. C., Meyer J. F., McNay J. L. Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs. Am J Cardiol. 1971 Apr;27(4):384–391. doi: 10.1016/0002-9149(71)90435-8. [DOI] [PubMed] [Google Scholar]
  9. Vatner S. F., Higgins C. B., Braunwald E. Effects of norepinephrine on coronary circulation and left ventricular dynamics in the conscious dog. Circ Res. 1974 Jun;34(6):812–823. doi: 10.1161/01.res.34.6.812. [DOI] [PubMed] [Google Scholar]
  10. Wackers F. J., Lie K. I., Becker A. E., Durrer D., Wellens H. J. Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction. Br Heart J. 1976 Sep;38(9):906–910. doi: 10.1136/hrt.38.9.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Weissler A. M., Harris W. S., Schoenfeld C. D. Systolic time intervals in heart failure in man. Circulation. 1968 Feb;37(2):149–159. doi: 10.1161/01.cir.37.2.149. [DOI] [PubMed] [Google Scholar]
  12. Willerson J. T., Hutton I., Watson J. T., Platt M. R., Templeton G. H. Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs. Circulation. 1976 May;53(5):828–833. doi: 10.1161/01.cir.53.5.828. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES