Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1980 Feb;43(2):220–225. doi: 10.1136/hrt.43.2.220

Haemodynamic effects of oral salbutamol alone and in combination with sublingual isosorbide dinitrate in patients with severe congestive cardiac failure.

J D Stephens, S O Banim, R A Spurrell
PMCID: PMC482266  PMID: 7362716

Abstract

To examine possible augmentation of the effects of isosorbide dinitrate by salbutamol, haemodynamic measurements were made in 10 patients with severe chronic congestive cardiac failure who received isosorbide dinitrate 2.5 to 25 mg sublingually and salbutamol 4 to 12 mg orally, alone and in combination. Isosorbide dinitrate reduced mean left ventricular filling pressure from 29 to 18 mmHg and increased mean cardiac index from 1.7 to 2.0 1/min per m2, with no significant change in mean heart rate. Systemic arterial mean pressure fell from 85 to 72 mmHg. Salbutamol increased cardiac index from 1.8 to 2.2 1/min per m2. There was no significant change in left ventricular filling pressure, heart rate, or systemic arterial pressure. Compared with control, combined isosorbide dinitrate and salbutamol reduced left ventricular filling pressure from 27 to 19 mmHg and increased cardiac index from 1.8 to 2.7 1/min per m2, with no significant change in heart rate. Systemic arterial pressure fell from 82 to 75 mmHg. The reduction in left ventricular filling pressure by combined treatment was similar to that produced by isosorbide dinitrate alone, but the increase in cardiac index was significantly greater than that produced either by isosorbide dinitrate alone or salbutamol alone. Combined sublingual isosorbide dinitrate and oral salbutamol have an additive effect in improving left ventricular performance in patients with severe chronic congestive cardiac failure.

Full text

PDF
220

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beregovich J., Bianchi C., Rubler S., Lomnitz E., Cagin N., Levitt B. Dose-related hemodynamic and renal effects of dopamine in congestive heart failure. Am Heart J. 1974 May;87(5):550–557. doi: 10.1016/0002-8703(74)90491-8. [DOI] [PubMed] [Google Scholar]
  2. Chatterjee K., Parmley W. W., Ganz W., Forrester J., Walinsky P., Crexells C., Swan H. J. Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation. 1973 Dec;48(6):1183–1193. doi: 10.1161/01.cir.48.6.1183. [DOI] [PubMed] [Google Scholar]
  3. Cullum V. A., Farmer J. B., Jack D., Levy G. P. Salbutamol: a new, selective beta-adrenoceptive receptor stimulant. Br J Pharmacol. 1969 Jan;35(1):141–151. doi: 10.1111/j.1476-5381.1969.tb07975.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Daly M. J., Farmer J. B., Levy G. P. Comparison of the bronchodilator and cardiovascular actions of salbutamol, isoprenaline and orciprenaline in guinea-pigs and dogs. Br J Pharmacol. 1971 Nov;43(3):624–638. doi: 10.1111/j.1476-5381.1971.tb07192.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dymond D. S., Jarritt P. H., Britton K. E., Spurrell R. A. Detection of postinfarction left ventricular aneurysms by first pass radionuclide ventriculography using a multicrystal gamma camera. Br Heart J. 1979 Jan;41(1):68–78. doi: 10.1136/hrt.41.1.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Franciosa J. A., Limas C. J., Guiha N. H., Rodriguera E., Cohn J. N. Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet. 1972 Mar 25;1(7752):650–654. doi: 10.1016/s0140-6736(72)90460-6. [DOI] [PubMed] [Google Scholar]
  7. Ganz W., Swan H. J. Measurement of blood flow by thermodilution. Am J Cardiol. 1972 Feb;29(2):241–246. doi: 10.1016/0002-9149(72)90635-2. [DOI] [PubMed] [Google Scholar]
  8. Gray R., Chatterjee K., Vyden J. K., Ganz W., Forrester J. S., Swan H. J. Hemodynamic and metabolic effects of isosorbide dinitrate in chronic congestive heart failure. Am Heart J. 1975 Sep;90(3):346–352. doi: 10.1016/0002-8703(75)90324-5. [DOI] [PubMed] [Google Scholar]
  9. KAISER G. A., ROSS J., Jr, BRAUNWALD E. ALPHA AND BETA ADRENERGIC RECEPTOR MECHANISMS IN THE SYSTEMIC VENOUS BED. J Pharmacol Exp Ther. 1964 May;144:156–162. [PubMed] [Google Scholar]
  10. Leier C. V., Webel J., Bush C. A. The cardiovascular effects of the continuous infusion of dobutamine in patients with severe cardiac failure. Circulation. 1977 Sep;56(3):468–472. doi: 10.1161/01.cir.56.3.468. [DOI] [PubMed] [Google Scholar]
  11. Miller R. R., Awan N. A., Joye J. A., Maxwell K. S., DeMaria A. N., Amsterdam E. A., Mason D. T. Combined dopamine and nitroprusside therapy in congestive heart failure. Greater augmentation of cardiac performance by addition of inotropic stimulation to afterload reduction. Circulation. 1977 Jun;55(6):881–884. doi: 10.1161/01.cir.55.6.881. [DOI] [PubMed] [Google Scholar]
  12. Sharma B., Goodwin J. F. Beneficial effect of salbutamol on cardiac function in severe congestive cardiomyopathy. Effect on systolic and diastolic function of the left ventricle. Circulation. 1978 Sep;58(3 Pt 1):449–460. doi: 10.1161/01.cir.58.3.449. [DOI] [PubMed] [Google Scholar]
  13. Stephens J., Camm J., Spurrell R. Improvement in exercise haemodynamics by isosorbide dinitrate in patients with severe congestive cardiac failure secondary to ischaemic heart disease. Br Heart J. 1978 Aug;40(8):832–837. doi: 10.1136/hrt.40.8.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stephens J., Dymond D., Spurrell R. Enhancement by isosorbide dinitrate of haemodynamic effects of dopamine in chronic congestive cardiac failure. Br Heart J. 1978 Aug;40(8):838–844. doi: 10.1136/hrt.40.8.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Williams D. O., Bommer W. J., Miller R. R., Amsterdam E. A., Mason D. T. Hemodynamic assessment of oral peripheral vasodilator therapy in chronic congestive heart failure: prolonged effectiveness of isosorbide dinitrate. Am J Cardiol. 1977 Jan;39(1):84–90. doi: 10.1016/s0002-9149(77)80016-7. [DOI] [PubMed] [Google Scholar]
  16. Wyse S. D., Gibson D. G., Branthwaite M. A. Haemodynamic effects of salbutamol in patients needing circulatory support after open-heart surgery. Br Med J. 1974 Aug 24;3(5929):502–503. doi: 10.1136/bmj.3.5929.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Zsotér T. T., Epstein S. W. Effect of salbutamol on the peripheral circulation in man. Chest. 1973 Oct;64(4):465–471. doi: 10.1378/chest.64.4.465. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES