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. 2015 Oct 24;7(3):2354–2366. doi: 10.18632/oncotarget.6221

Figure 5. Knockdown of TREM2 in glioma cells reduced tumor growth in vivo.

Figure 5

A. U87 cells transfected with siRNA control (NC) or TREM2-siRNA were subcutaneously injected in athymic nude mice. Tumor growth was shown 36 days after injection. B. Time course analysis of tumor growth after injection (**P < 0.01 compared with NC). C. Mice were sacrificed and the tumors were isolated after 36 days. D. Tumor growth was significantly reduced in TREM2 knockdown tumors (P < 0.0001). E. Transplanted tumors with Ki67 immunostaining and TUNEL staining. F. The expression of TREM2, PCNA, MMP2 and MMP9 in xenograft from the nude mice was determined by western blot (**P < 0.01, ***P < 0.001 compared with NC).