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. 2015 Oct 16;7(3):2433–2454. doi: 10.18632/oncotarget.5693

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Copyright: © 2016 Uziel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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A. Telomerase activity as measured by the TRAP assay before and after BRCA1 silencing. B. hTERT expression measured by real time PCR before and after BRCA1 silencing. “WT”- the wild type cells; “NC”- cells transfected with the negative control shRNA plasmid; “4” is clone # 4 in which BRCA1 silencing was optimal 6 months post shRNA transfection. C. Induction of telomerase activity by PHA in BRCA1/2 mutations carriers. Mononuclear cells were isolated from the BRCA1/2 mutation carriers as well as from the control group and subjected to PHA. Subsequently, telomerase activity was measured by the TRAP assay.

A. Telomerase activity as measured by the TRAP assay before and after BRCA1 silencing. B. hTERT expression measured by real time PCR before and after BRCA1 silencing. “WT”- the wild type cells; “NC”- cells transfected with the negative control shRNA plasmid; “4” is clone # 4 in which BRCA1 silencing was optimal 6 months post shRNA transfection. C. Induction of telomerase activity by PHA in BRCA1/2 mutations carriers. Mononuclear cells were isolated from the BRCA1/2 mutation carriers as well as from the control group and subjected to PHA. Subsequently, telomerase activity was measured by the TRAP assay.