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. 1980 May;43(5):523–526. doi: 10.1136/hrt.43.5.523

Salbutamol in cardiogenic shock complicating acute myocardial infarction.

J R Dawson, P A Poole-Wilson, G C Sutton
PMCID: PMC482335  PMID: 7378211

Abstract

Intravenous salbutamol (13 microgram/min) has been given to 31 patients with cardiogenic shock complicating acute myocardial infarction. Haemodynamic measurements were made in nine of these patients. Salbutamol increased cardiac index by 41 per cent from 1.25 +/- 0.06 l/min per m2 to 1.76 +/- 0.19 l/min per m2 and decreased systemic vascular resistance by 16 per cent from 26.2 +/- 1.9 units to 21.9 +/- 2.1 units. Heart rate rose by 13 per cent from 95 +/- 4.5 beats/min to 106 +/- 6.0 beats/min. Pulmonary artery end-diastolic pressure fell from 20.6 +/- 1.7 mmHg to 16.9+/- 1.9 mmHg. Of the 31 patients, eight survived to leave hospital (27%). Five of the survivors had initial low heart rates and in these patients the clinical improvement was probably attributable to the positive chronotropic action of salbutamol. In the remaining three survivors clinical improvement was probably a result of salbutamol mediated afterload reduction. Salbutamol may be useful in the treatment of cardiogenic shock and pump failure complicating acute myocardial infarction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxter R. H., Tait C. M., McGuinness J. B. Vasodilator therapy in acute myocardial infarction. Use of sublingual isosorbide dinitrate. Br Heart J. 1977 Oct;39(10):1067–1070. doi: 10.1136/hrt.39.10.1067. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bourdillon P. D., Dawson J. R., Foale R. A., Timmis A. D., Poole-Wilson P. A., Sutton G. C. Salbutamol in treatment of heart failure. Br Heart J. 1980 Feb;43(2):206–210. doi: 10.1136/hrt.43.2.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Braunwald E. Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol. 1971 Apr;27(4):416–432. doi: 10.1016/0002-9149(71)90439-5. [DOI] [PubMed] [Google Scholar]
  4. Chatterjee K., Parmley W. W. Vasodilator treatment for acute and chronic heart failure. Br Heart J. 1977 Jul;39(7):706–720. doi: 10.1136/hrt.39.7.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Choo-Kang Y. F., Simpson W. T., Grant I. W. Controlled comparison of the bronchodilator effects of three beta-adrenergic stimulant drugs administered by inhalation to patients with asthma. Br Med J. 1969 May 3;2(5652):287–289. doi: 10.1136/bmj.2.5652.287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cullum V. A., Farmer J. B., Jack D., Levy G. P. Salbutamol: a new, selective beta-adrenoceptive receptor stimulant. Br J Pharmacol. 1969 Jan;35(1):141–151. doi: 10.1111/j.1476-5381.1969.tb07975.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Flaherty J. T., Reid P. R., Kelly D. T., Taylor D. R., Weisfeldt M. L., Pitt B. Intravenous nitroglycerin in acute myocardial infarction. Circulation. 1975 Jan;51(1):132–139. doi: 10.1161/01.cir.51.1.132. [DOI] [PubMed] [Google Scholar]
  8. Franciosa J. A., Limas C. J., Guiha N. H., Rodriguera E., Cohn J. N. Improved left ventricular function during nitroprusside infusion in acute myocardial infarction. Lancet. 1972 Mar 25;1(7752):650–654. doi: 10.1016/s0140-6736(72)90460-6. [DOI] [PubMed] [Google Scholar]
  9. Ganz W., Swan H. J. Measurement of blood flow by thermodilution. Am J Cardiol. 1972 Feb;29(2):241–246. doi: 10.1016/0002-9149(72)90635-2. [DOI] [PubMed] [Google Scholar]
  10. Kelly D. T., Delgado C. E., Taylor D. R., Pitt B., Ross R. S. Use of phentolamine in acute myocardial infarction associated with hypertension and left ventricular failure. Circulation. 1973 Apr;47(4):729–735. doi: 10.1161/01.cir.47.4.729. [DOI] [PubMed] [Google Scholar]
  11. Lal S., Savidge R. S., Davies D. M., Ali M. M., Soni V. Intravenous salbutamol and cardiogenic shock. Lancet. 1972 Apr 15;1(7755):853–854. doi: 10.1016/s0140-6736(72)90846-x. [DOI] [PubMed] [Google Scholar]
  12. Nayler W. G. Some observations on the pharmacological effects of salbutamol, with particular reference to the cardiovascular system. Postgrad Med J. 1971 Mar;47(Suppl):16–21. [PubMed] [Google Scholar]
  13. Poole-Wilson P. A., Lewis G., Angerpointer T., Malcolm A. D., Williams B. T. Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery. Br Heart J. 1977 Jul;39(7):721–725. doi: 10.1136/hrt.39.7.721. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Resnekov L. Circulatory assistance for the failing heart. Br Heart J. 1973 Dec;35(12):1265–1270. doi: 10.1136/hrt.35.12.1265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sharma B., Goodwin J. F. Beneficial effect of salbutamol on cardiac function in severe congestive cardiomyopathy. Effect on systolic and diastolic function of the left ventricle. Circulation. 1978 Sep;58(3 Pt 1):449–460. doi: 10.1161/01.cir.58.3.449. [DOI] [PubMed] [Google Scholar]
  16. Wyse S. D., Gibson D. G., Branthwaite M. A. Haemodynamic effects of salbutamol in patients needing circulatory support after open-heart surgery. Br Med J. 1974 Aug 24;3(5929):502–503. doi: 10.1136/bmj.3.5929.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Yacoub M. H., Boyland E. Cardiovascular effects of intravenous salbutamol after open heart operations. Lancet. 1973 Jun 2;1(7814):1260–1261. doi: 10.1016/s0140-6736(73)90583-7. [DOI] [PubMed] [Google Scholar]

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