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. 1980 Aug;44(2):134–142. doi: 10.1136/hrt.44.2.134

Adverse effects of beta-blockade withdrawal in patients with congestive cardiomyopathy.

K Swedberg, A Hjalmarson, F Waagstein, I Wallentin
PMCID: PMC482372  PMID: 6107091

Abstract

Fifteen patients with congestive cardiomyopathy who had improved conspicuously on chronic administration of a beta-blocker were studied after withdrawal of the drug. In six patients there was a pronounced deterioration of their clinical condition, and in all of the remaining patients there was a significant decrease in ejection fraction, and signs of compromised diastolic function with pathological apex curves and an increase in third heart sound. All these changes were reversed within a few weeks to a few months after readministration of beta-blocking drugs. This study supports the idea that an aetiological factor in congestive cardiomyopathy may be a pathological response to sympathetic stimulation which could be partly controlled by administration of beta-blocking drugs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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