Abstract
We describe eight patients treated for angina with prenylamine who developed life-threatening ventricular arrhythmias after QT interval prolongation. When prenylamine administration was stopped QT interval shortened to within normal values, while the ventricular arrhythmias were controlled by a temporary ventricular pacemaker and disappeared after several days. We stress the importance of surveillance of the QT interval and ventricular arrhythmias in patients receiving long-term treatment with prenylamine.
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- Chiche P., Haiat R., Steff P. Angina pectoris with syncope due to paroxysmal atrioventricular block: role of ischaemia. Report of two cases. Br Heart J. 1974 Jun;36(6):577–581. doi: 10.1136/hrt.36.6.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans T. R., Curry P. V., Fitchett D. H., Krikler D. M. "Torsade de pointes" initiated by electrical ventricular stimulation. J Electrocardiol. 1976;9(3):255–258. doi: 10.1016/s0022-0736(76)80053-2. [DOI] [PubMed] [Google Scholar]
- Fazzini P. F., Marchi F., Pucci P. Q-T lungo, sincope e prenilamina. G Ital Cardiol. 1973;3(2):233–239. [PubMed] [Google Scholar]
- Fazzini P., Marchi F. Ventricular tachycardia: a new iatrogenic possibility. Am Heart J. 1975 Dec;90(6):805–806. doi: 10.1016/0002-8703(75)90473-1. [DOI] [PubMed] [Google Scholar]
- Finley J. P., Radford D. J., Freedom R. M. Torsade de pointes ventricular tachycardia in a newborn infant. Br Heart J. 1978 Apr;40(4):421–424. doi: 10.1136/hrt.40.4.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fowler N. O., McCall D., Chou T. C., Holmes J. C., Hanenson I. B. Electrocardiographic changes and cardiac arrhythmias in patients receiving psychotropic drugs. Am J Cardiol. 1976 Feb;37(2):223–230. doi: 10.1016/0002-9149(76)90316-7. [DOI] [PubMed] [Google Scholar]
- Gupta P. K., Lichstein E., Chadda K. D. Lidocaine-induced heart block in patients with bundle branch block. Am J Cardiol. 1974 Apr;33(4):487–492. doi: 10.1016/0002-9149(74)90606-7. [DOI] [PubMed] [Google Scholar]
- Han J., Millet D., Chizzonitti B., Moe G. K. Temporal dispersion of recovery of excitability in atrium and ventricle as a function of heart rate. Am Heart J. 1966 Apr;71(4):481–487. doi: 10.1016/0002-8703(66)90213-4. [DOI] [PubMed] [Google Scholar]
- ITO Y., HASEGAWA Y. The effect of coronary vasodilators on the coronary circulation and the myocardial metabolism in the sclerotic heart diseases. Jpn Circ J. 1963 Feb;27:164–171. doi: 10.1253/jcj.27.164. [DOI] [PubMed] [Google Scholar]
- JERVELL A., LANGE-NIELSEN F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J. 1957 Jul;54(1):59–68. doi: 10.1016/0002-8703(57)90079-0. [DOI] [PubMed] [Google Scholar]
- LEVINE S. A., WOODWORTH C. R. Congenital deaf-mutism, prolonged QT interval, syncopal attacks and sudden death. N Engl J Med. 1958 Aug 28;259(9):412–417. doi: 10.1056/NEJM195808282590902. [DOI] [PubMed] [Google Scholar]
- Picard R., Auzepy P., Chauvin J. P. Syncopes et alterations electrocardiographiques provoquees par la prenylamine. Ann Cardiol Angeiol (Paris) 1971 Sep-Oct;20(5):627–630. [PubMed] [Google Scholar]
- Puritz R., Henderson M. A., Baker S. N., Chamberlain D. A. Ventricular arrhythmias caused by prenylamine. Br Med J. 1977 Sep 3;2(6087):608–609. doi: 10.1136/bmj.2.6087.608. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROMANO C., GEMME G., PONGIGLIONE R. ARITMIE CARDIACHE RARE DELL'ETA' PEDIATRICA. II. ACCESSI SINCOPALI PER FIBRILLAZIONE VENTRICOLARE PAROSSISTICA. (PRESENTAZIONE DEL PRIMO CASO DELLA LETTERATURA PEDIATRICA ITALIANA) Clin Pediatr (Bologna) 1963 Sep;45:656–683. [PubMed] [Google Scholar]
- Schoonmaker F. W., Osteen R. T., Greenfield J. C., Jr Thioridazine (mellaril)-induced ventricular tachycardia controlled with an artificial pacemaker. Ann Intern Med. 1966 Nov;65(5):1076–1078. doi: 10.7326/0003-4819-65-5-1076. [DOI] [PubMed] [Google Scholar]
- Singh B. N., Gaarder T. D., Kanegae T., Goldstein M., Montgomerie J. Z., Mills H. Liquid protein diets and torsade de pointes. JAMA. 1978 Jul 14;240(2):115–119. [PubMed] [Google Scholar]
- Stoker J. B. Effect of prenylamine in angina pectoris. Br J Clin Pract. 1968 Sep;22(9):384–385. [PubMed] [Google Scholar]
- Tucker H., Carson P., Bass N., Massey J. Prenylamine in treatment of angina. Br Heart J. 1974 Oct;36(10):1001–1004. doi: 10.1136/hrt.36.10.1001. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WARD O. C. A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN. J Ir Med Assoc. 1964 Apr;54:103–106. [PubMed] [Google Scholar]






