Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1981 Apr;45(4):385–388. doi: 10.1136/hrt.45.4.385

Haemodynamic effects of prostacyclin (PGI2) in pulmonary hypertension.

D N Guadagni, H Ikram, A H Maslowski
PMCID: PMC482538  PMID: 7013775

Abstract

An infusion of prostacyclin (PGI2) in four patients with pulmonary hypertension resulted in a dose-related decrease in the systemic and pulmonary vascular resistance and an increase in cardiac output. No selectivity for the pulmonary vasculature was observed and the drug was not therapeutically beneficial.

Full text

PDF
385

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bourdillon P. D., Oakley C. M. Regression of primary pulmonary hypertension. Br Heart J. 1976 Mar;38(3):264–270. doi: 10.1136/hrt.38.3.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Charters A. D., Baker W. de C. Primary pulmonary hypertension of unusually long duration. Br Heart J. 1970 Jan;32(1):130–133. doi: 10.1136/hrt.32.1.130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Daoud F. S., Reeves J. T., Kelly D. B. Isoproterenol as a potential pulmonary vasodilator in primary pulmonary hypertension. Am J Cardiol. 1978 Nov;42(5):817–822. doi: 10.1016/0002-9149(78)90102-9. [DOI] [PubMed] [Google Scholar]
  4. Edwards W. D., Edwards J. E. Clinical primary pulmonary hypertension: three pathologic types. Circulation. 1977 Nov;56(5):884–888. doi: 10.1161/01.cir.56.5.884. [DOI] [PubMed] [Google Scholar]
  5. Gryglewski R. J., Korbut R., Ocetkiewicz A. Generation of prostacyclin by lungs in vivo and its release into the arterial circulation. Nature. 1978 Jun 29;273(5665):765–767. doi: 10.1038/273765a0. [DOI] [PubMed] [Google Scholar]
  6. Hyman A. L., Kadowitz P. J. Pulmonary vasodilator activity of prostacyclin (PGI2) in the cat. Circ Res. 1979 Sep;45(3):404–409. doi: 10.1161/01.res.45.3.404. [DOI] [PubMed] [Google Scholar]
  7. Kadowitz P. J., Chapnick B. M., Feigen L. P., Hyman A. L., Nelson P. K., Spannhake E. W. Pulmonary and systemic vasodilator effects of the newly discovered prostaglandin, PGI2. J Appl Physiol Respir Environ Exerc Physiol. 1978 Sep;45(3):408–413. doi: 10.1152/jappl.1978.45.3.408. [DOI] [PubMed] [Google Scholar]
  8. Landmark K., Refsum A. M., Simonsen S., Storstein O. Verapamil and pulmonary hypertension. Acta Med Scand. 1978;204(4):299–302. doi: 10.1111/j.0954-6820.1978.tb08443.x. [DOI] [PubMed] [Google Scholar]
  9. Lock J. E., Olley P. M., Coceani F., Swyer P. R., Rowe R. D. Use of prostacyclin in persistent fetal circulation. Lancet. 1979 Jun 23;1(8130):1343–1343. doi: 10.1016/s0140-6736(79)91970-6. [DOI] [PubMed] [Google Scholar]
  10. Moncada S., Gryglewski R., Bunting S., Vane J. R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976 Oct 21;263(5579):663–665. doi: 10.1038/263663a0. [DOI] [PubMed] [Google Scholar]
  11. Nagasaka Y., Akutsu H., Lee Y. S., Fujimoto S., Chikamori J. Longterm favorable effect of oxygen administration on a patient with primary pulmonary hypertension. Chest. 1978 Sep;74(3):299–300. doi: 10.1378/chest.74.3.299. [DOI] [PubMed] [Google Scholar]
  12. Ruskin J. N., Hutter A. M., Jr Primary pulmonary hypertension treated with oral phentolamine. Ann Intern Med. 1979 May;90(5):772–774. doi: 10.7326/0003-4819-90-5-772. [DOI] [PubMed] [Google Scholar]
  13. Shettigar U. R., Hultgren H. N., Specter M., Martin R., Davies D. H. Primary pulmonary hypertension favorable effect of isoproterenol. N Engl J Med. 1976 Dec 16;295(25):1414–1415. doi: 10.1056/NEJM197612162952506. [DOI] [PubMed] [Google Scholar]
  14. Szczeklik J., Dubiel J. S., Mysik M., Pyzik Z., Krol R., Horzela T. Effects of prostaglandin E1 on pulmonary circulation in patients with pulmonary hypertension. Br Heart J. 1978 Dec;40(12):1397–1401. doi: 10.1136/hrt.40.12.1397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Walcott G., Burchell H. B., Brown A. L., Jr Primary pulmonary hypertension. Am J Med. 1970 Jul;49(1):70–79. doi: 10.1016/s0002-9343(70)80115-2. [DOI] [PubMed] [Google Scholar]
  16. Wang S. W., Pohl J. E., Rowlands D. J., Wade E. G. Diazoxide in treatment of primary pulmonary hypertension. Br Heart J. 1978 May;40(5):572–574. doi: 10.1136/hrt.40.5.572. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES