Abstract
We studied the acute effects of nifedipine on left ventricular function and haemodynamics at constant heart rate in patients on beta-blocker therapy. Nifedipine significantly depressed left ventricular peak dP/dt and peak dP/dt x P-1. Nifedipine also significantly reduced systemic vascular resistance: this was associated with decreased systolic blood pressure and increased left ventricular stroke output, with slight non-significant increases of ejection fraction and mean circumferential shortening velocity. There was no change in left ventricular end-diastolic pressure. This clinical study shows that nifedipine increases cardiac output in association with arterial dilatation despite evidence for a negative inotropic effect. Such intrinsic negative inotropic effects would normally be masked by compensatory sympathetic activity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHIDSEY C. A., BRAUNWALD E., MORROW A. G. CATECHOLAMINE EXCRETION AND CARDIAC STORES OF NOREPINEPHRINE IN CONGESTIVE HEART FAILURE. Am J Med. 1965 Sep;39:442–451. doi: 10.1016/0002-9343(65)90211-1. [DOI] [PubMed] [Google Scholar]
- Chidsey C. A., Sonnenblick E. H., Morrow A. G., Braunwald E. Norepinephrine stores and contractile force of papillary muscle from the failing human heart. Circulation. 1966 Jan;33(1):43–51. doi: 10.1161/01.cir.33.1.43. [DOI] [PubMed] [Google Scholar]
- Karliner J. S., Gault J. H., Eckberg D., Mullins C. B., Ross J., Jr Mean velocity of fiber shortening. A simplified measure of left ventricular myocardial contractility. Circulation. 1971 Sep;44(3):323–333. doi: 10.1161/01.cir.44.3.323. [DOI] [PubMed] [Google Scholar]
- Kasser I. S., Kennedy J. W. Measurement of left ventricular volumes in man by single-plane cineangiocardiography. Invest Radiol. 1969 Mar-Apr;4(2):83–90. doi: 10.1097/00004424-196904020-00005. [DOI] [PubMed] [Google Scholar]
- Nejad N. S., Klein M. D., Mirsky I., Lown B. Assessment of myocardial contractility from ventricular pressure recordings. Cardiovasc Res. 1971 Jan;5(1):15–23. doi: 10.1093/cvr/5.1.15. [DOI] [PubMed] [Google Scholar]
- Noble M. I., Stubbs J., Trenchard D., Else W., Eisele J. H., Guz A. Left ventricular performance in the conscious dog with chronically denervated heart. Cardiovasc Res. 1972 Sep;6(5):457–475. doi: 10.1093/cvr/6.5.457. [DOI] [PubMed] [Google Scholar]