Figure 5. Knock-down of CD95 abolishes sildenafil and DOX-induced toxicity in DU145 cells.
Upper panel shows knock-down of CD95 by siRNAs. Bar chart represents cell death following knock-down of CD95 with siRNA or scramble RNA (siSCR as control) and 24 hr treatment with DOX (0.5 μM) and/or Sild (10 μM). Abbreviations: doxorubicin – DOX; Sildenafil – Sild.