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. 2016 Apr 4;10(2):024117. doi: 10.1063/1.4945309

FIG. 5.

FIG. 5.

Intracellular calcium signalling response of HEK-293-TRPV4 cells under concurrent shear stress and GSK1016790A stimulation. (a)–(c) Normalised intensity profiles at different concentrations of GSK1016790A (control (0.0 nM), 3.125 nM, and 12.5 nM, respectively), obtained at the reference shear values of (i) 0.875, (ii) 12.5, and (iii) 42 dyn/cm2 (see supplementary material S8 for experimental fluorescent images).46 (d) Comparing the response characteristics: (i) cellular and (ii) peak response times, and (iii) pharmacological efficacy of cells under different shear stress levels. Data are presented as the mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.