Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1981 Sep;46(3):296–301. doi: 10.1136/hrt.46.3.296

Heart antibodies in cardiomyopathies.

T Trueman, R A Thompson, P Cummins, W A Littler
PMCID: PMC482648  PMID: 7028058

Abstract

The reported frequency of circulating heart reactive antibodies in cardiomyopathies has varied and their significance is unknown. In this study such antibodies were sought in patients with primary congestive and hypertrophic cardiomyopathies and other heart diseases. Standard "single sandwich" and the more sensitive "double sandwich" indirect immunofluorescence techniques failed to disclose a significant difference between any cardiomyopathic group and controls in repeated experiments. With both techniques results were subject to considerable method-specific artefacts and observer variation. No published work associating heart antibodies detected by immunofluorescence methods with cariomyopathies adequately takes these into account.

Full text

PDF
296

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bauer H., Waters T. J., Talano J. V. Antimyocardial antibodies in patients with coronary heart disease. Am Heart J. 1972 May;83(5):612–619. doi: 10.1016/0002-8703(72)90400-0. [DOI] [PubMed] [Google Scholar]
  2. Camp T. F., Hess E. V., Conway G., Fowler N. O. Immunologic findings in idiopathic cardiomyopathy. Am Heart J. 1969 May;77(5):610–618. doi: 10.1016/0002-8703(69)90545-6. [DOI] [PubMed] [Google Scholar]
  3. Das S. K., Cassidy J. T. Antiheart antibodies in patients with systemic lupus erythematosus. Am J Med Sci. 1973 Apr;265(4):275–280. doi: 10.1097/00000441-197304000-00002. [DOI] [PubMed] [Google Scholar]
  4. Das S. K., Cassidy J. T., Dodson V. N., Willis R. W., 3rd Antiheart antibody in idiopathic hypertrophic subaortic stenosis. Br Heart J. 1973 Sep;35(9):965–969. doi: 10.1136/hrt.35.9.965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Espinosa E., Kaplan M. H. Antigenic analysis of human heart tissue. Antigens with restricted organ distribution in acid extracts of human myocardium. J Immunol. 1970 Aug;105(2):416–425. [PubMed] [Google Scholar]
  6. Fletcher G. F., Wenger N. K. Autoimmune studies in patients with primary myocardial disease. Circulation. 1968 Jun;37(6):1032–1035. doi: 10.1161/01.cir.37.6.1032. [DOI] [PubMed] [Google Scholar]
  7. Gaul G., Ludwig H., Steffen C. Vergleichende Untersuchung über das Vorkommen herzreaktiver Antikörper als Aktivitätsnachweis bei rheumatischen Herzerkrankungen mittels Humanherz- und Affenherzantigen im Konsumptionstest und Immunfluoreszenztest. Wien Klin Wochenschr. 1974 Oct 4;86(18):532–539. [PubMed] [Google Scholar]
  8. Goodwin J. E. Clarification of the cardiomyopathies. Mod Concepts Cardiovasc Dis. 1972 Sep;41(9):41–46. [PubMed] [Google Scholar]
  9. Kirsner A. B., Hess E. V., Fowler N. O. Immunologic findings in idiopathic cardiomyopathy: a prospective serial study. Am Heart J. 1973 Nov;86(5):625–630. doi: 10.1016/0002-8703(73)90339-6. [DOI] [PubMed] [Google Scholar]
  10. Klajman A., Kamin-Belsky N., Feldman S., Kariv I. Immunologic studies in familial cardiomyopathy. Am J Cardiol. 1971 Dec;28(6):707–711. doi: 10.1016/0002-9149(71)90059-2. [DOI] [PubMed] [Google Scholar]
  11. Nicholson G. C., Dawkins R. L., McDonald B. L., Wetherall J. D. A classification of anti-heart antibodies: differentiation between heart-specific and heterophile antibodies. Clin Immunol Immunopathol. 1977 May;7(3):349–363. doi: 10.1016/0090-1229(77)90069-1. [DOI] [PubMed] [Google Scholar]
  12. Oevermann W., Bolte H. D., Zwehl W. Indirekter Immunfluorescenztest und indirekter Antiglobulinkonsumptionstest in der Diagnostik primärer Kardiomyopathien. Verh Dtsch Ges Inn Med. 1973;79:1121–1124. [PubMed] [Google Scholar]
  13. Robinson J. A., Grieble H. G., Anderson T. O. The serological abnormalities of idiopathic myocardial disease. Cardiovasc Res. 1970 Jan;4(1):14–22. doi: 10.1093/cvr/4.1.14. [DOI] [PubMed] [Google Scholar]
  14. Sack W., Sebening H., Wachsmuth E. D. Auto-Antikörper gegen Herzmuskelsarkolemm im Serum von Patienten mit primärer Cardiomyopathie. Klin Wochenschr. 1975 Feb 1;53(3):103–110. doi: 10.1007/BF01466712. [DOI] [PubMed] [Google Scholar]
  15. Shaper A. G., Kaplan M. H., Foster W. D., Macintosh D. M., Wilks N. E. Immunological studies in endomyocardial fibrosis and other forms of heart-disease in the tropics. Lancet. 1967 Mar 18;1(7490):598–600. doi: 10.1016/s0140-6736(67)90445-x. [DOI] [PubMed] [Google Scholar]
  16. VAN DER GELD H. ANTI-HEART ANTIBODIES IN THE POSTPERICARDIOTOMY AND THE POSTMYOCARDIAL-INFARCTION SYNDROMES. Lancet. 1964 Sep 19;2(7360):617–621. doi: 10.1016/s0140-6736(64)90512-4. [DOI] [PubMed] [Google Scholar]
  17. Wilson F. M., Miranda Q. R., Chason J. L., Lerner A. M. Residual pathologic changes following murine coxsackie A and B myocarditis. Am J Pathol. 1969 May;55(2):253–265. [PMC free article] [PubMed] [Google Scholar]
  18. Zabriskie J. B., Hsu K. C., Seegal B. C. Heart-reactive antibody associated with rheumatic fever: characterization and diagnostic significance. Clin Exp Immunol. 1970 Aug;7(2):147–159. [PMC free article] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES