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. 1981 Nov;46(5):545–551. doi: 10.1136/hrt.46.5.545

Cardiovascular status in asymptomatic alcoholics, with reference to the level of ethanol consumption.

M Kino, H Imamitchi, M Morigutchi, K Kawamura, T Takatsu
PMCID: PMC482694  PMID: 7317220

Abstract

One hundred and forty-five alcoholics without known causes of heart disease, who were serially admitted to the alcohol detoxification centre, were studied to see the incidence of cardiac abnormalities and dose related effects of ethanol. All patients were divided into heavy (consumed more than the equivalent amount of 125 ml of pure ethanol daily for 10 years or more) and moderate drinkers (consumed 75 to 125 ml of ethanol daily). All of them were ambulatory and free from cardiac symptoms. There was no difference among heavy and moderate drinkers in the incidence of abnormalities detected by the electrocardiograms and chest x-ray films. In the alcoholics, the most frequent finding was a prolonged QTc interval of more than 0.44 s on the electrocardiogram (62 patients, 42.8%), unrelated to serum electrolytes imbalance. Cardiomegaly on chest x-ray film was observed in 25 patients (17.2%). M-mode echocardiogram was recorded in randomly selected patients and compared with age and sex matched controls. The interventricular septum and posterior wall were thicker in alcoholics, while left ventricular volume showed no difference. Left ventricular muscle mass was significantly increased only in heavy drinkers. Left ventricular function at rest was not depressed in these patients at an average of 31 days after the last drink of ethanol. Severe heart failure was not found even among the group of heavy drinkers, of whom more than 90% had liver dysfunction. Cardiac hypertrophy seems to occur in heavy drinkers, but is clinically well compensated in the majority of alcoholics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander C. S. Idiopathic heart disease. I. Analysis of 100 cases, with special reference to chronic alcoholism. Am J Med. 1966 Aug;41(2):213–228. doi: 10.1016/0002-9343(66)90017-9. [DOI] [PubMed] [Google Scholar]
  2. Askanas A., Udoshi M., Sadjadi S. A. The heart in chronic alcoholism: a noninvasive study. Am Heart J. 1980 Jan;99(1):9–16. doi: 10.1016/0002-8703(80)90309-9. [DOI] [PubMed] [Google Scholar]
  3. Bing R. J. Cardiac metabolsim: its contributions to alcoholic heart disease and myocardial failure. Circulation. 1978 Dec;58(6):965–970. doi: 10.1161/01.cir.58.6.965. [DOI] [PubMed] [Google Scholar]
  4. Burch G. E., Giles T. D. Alcoholic cardiomyopathy. Concept of the disease and its treatment. Am J Med. 1971 Feb;50(2):141–145. doi: 10.1016/0002-9343(71)90143-4. [DOI] [PubMed] [Google Scholar]
  5. Cooper R. H., O'Rourke R. A., Karliner J. S., Peterson K. L., Leopold G. R. Comparison of ultrasound and cineangiographic measurements of the mean rate of circumferential fiber shortening in man. Circulation. 1972 Nov;46(5):914–923. doi: 10.1161/01.cir.46.5.914. [DOI] [PubMed] [Google Scholar]
  6. Devereux R. B., Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation. 1977 Apr;55(4):613–618. doi: 10.1161/01.cir.55.4.613. [DOI] [PubMed] [Google Scholar]
  7. EVANS W. The electrocardiogram of alcoholic cardiomyopathy. Br Heart J. 1959 Oct;21:445–456. doi: 10.1136/hrt.21.4.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hognestad J., Teisberg P. Heart pathology in chronic alcoholism. Acta Pathol Microbiol Scand A. 1973 May;81(3):315–322. doi: 10.1111/j.1699-0463.1973.tb03540.x. [DOI] [PubMed] [Google Scholar]
  9. Härtel G., Louhija A., Konttinen A. Cardiovascular study of 100 chronic alcoholics. Acta Med Scand. 1969 Jun;185(6):507–513. doi: 10.1111/j.0954-6820.1969.tb07376.x. [DOI] [PubMed] [Google Scholar]
  10. Kennedy J. W., Baxley W. A., Figley M. M., Dodge H. T., Blackmon J. R. Quantitative angiocardiography. I. The normal left ventricle in man. Circulation. 1966 Aug;34(2):272–278. doi: 10.1161/01.cir.34.2.272. [DOI] [PubMed] [Google Scholar]
  11. Koide T., Machida K., Nakanishi A., Ozeki K., Mashima S. Cardiac abnormalities in chronic alcoholism. An evidence suggesting association of myocardial abnormality with chronic alcoholism in 107 Japanese patients admitted to a psychiatric ward. Jpn Heart J. 1972 Sep;13(5):418–427. [PubMed] [Google Scholar]
  12. Luca C. Electrophysiological properties of right heart and atrioventricular conducting system in patients with alcoholic cardiomyopathy. Br Heart J. 1979 Sep;42(3):274–281. doi: 10.1136/hrt.42.3.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rankin J. G., Orrego-Matte H., Deschênes J., Medline A., Findlay J. E., Armstrong A. I. Alcoholic liver disease: the problem of diagnosis. Alcohol Clin Exp Res. 1978 Oct;2(4):327–338. doi: 10.1111/j.1530-0277.1978.tb04738.x. [DOI] [PubMed] [Google Scholar]
  14. Reeves W. C., Nanda N. C., Gramiak R. Echocardiography in chronic alcoholics following prolonged periods of abstinence. Am Heart J. 1978 May;95(5):578–583. doi: 10.1016/0002-8703(78)90299-5. [DOI] [PubMed] [Google Scholar]
  15. Regan T. J., Levinson G. E., Oldewurtel H. A., Frank M. J., Weisse A. B., Moschos C. B. Ventricular function in noncardiacs with alcoholic fatty liver: role of ethanol in the production of cardiomyopathy. J Clin Invest. 1969 Feb;48(2):397–407. doi: 10.1172/JCI105997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sahn D. J., DeMaria A., Kisslo J., Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978 Dec;58(6):1072–1083. doi: 10.1161/01.cir.58.6.1072. [DOI] [PubMed] [Google Scholar]
  17. Schenk E. A., Cohen J. The heart in chronic alcoholism. Clinical and pathologic findings. Pathol Microbiol (Basel) 1970;35(1):96–104. doi: 10.1159/000162206. [DOI] [PubMed] [Google Scholar]
  18. Spodick D. H., Pigott V. M., Chirife R. Preclinical cardiac malfunction in chronic alcoholism. Comparison with matched normal controls and with alcoholic cardiomyopathy. N Engl J Med. 1972 Oct 5;287(14):677–680. doi: 10.1056/NEJM197210052871401. [DOI] [PubMed] [Google Scholar]
  19. Teichholz L. E., Kreulen T., Herman M. V., Gorlin R. Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy. Am J Cardiol. 1976 Jan;37(1):7–11. doi: 10.1016/0002-9149(76)90491-4. [DOI] [PubMed] [Google Scholar]
  20. Tobin J. R., Jr, Driscoll J. F., Lim M. T., Sutton G. C., Szanto P. B., Gunnar R. M. Primary myocardial disease and alcoholism. The clinical manifestations and course of the disease in a selected population of patients observed for three or more years. Circulation. 1967 Apr;35(4):754–764. doi: 10.1161/01.cir.35.4.754. [DOI] [PubMed] [Google Scholar]

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