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. 1975 May;37(5):493–503. doi: 10.1136/hrt.37.5.493

Myocardial infarction in young men. Study of risk factors in nine countries.

M A Dolder, M F Oliver
PMCID: PMC482827  PMID: 1137658

Abstract

In order to determine whether the development of myocardial infarction in different countries is associated with different risk factors, 240 male survivors, aged 40 or less, were studied in nine countries. In the seven centres in developed countries (Auckland, Melbourne, Los Angles/Atlanta, Cape Town, Tel Avic, Heidelberg, and Edinburgh) there was a high procedure of risk factors, particularly of hyperlipidaemia and cigarette smoking. The prevalence of hypertension, obesity, hyperglycaemia, and hyperuricaemia varied from centre to centre. Risk factors were less prevalent in Bombay and Singapore: the most common risks operating in Bombay seemed to be cigarette smoking and hyperglycaemia, while in Singpore cigarette smoking was the commonest. The mean age of the whole group was 35.4 years. Serum cholesterol levels of 7.25 mmol/l (280 mg/dl) or more were present in 25 per cent of all patients, serum triglyceride levels of 2.26 mmol/l )l200 mg/dl) or more in 35 per cent. 80 per cent of the patients were smokers, and 15 per cent were either for hypertension before myocardial infarction or had a raised blood pressure after myocardial infarction. Obesity was found in 19 per cent of all patients and serum uric acid levels over 0.5 mmol/l (8.5 mg/dl) in 17 per cent. 10 per cent of all patients were either treated for diabetes mellitus before myocardial infarction or showed an abnormal glucose tolerance after myocardial infarction. This collaborative study may help, by showing differences in the prevalence of risk factors, to indicate to each centre and to national and to international organizations, the direction for their future studies into the causation and prevention of myocardial infarction in young men.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBRINK M. J., MEIGS J. W., MAN E. B. Serum lipids, hypertension and coronary artery disease. Am J Med. 1961 Jul;31:4–23. doi: 10.1016/0002-9343(61)90220-0. [DOI] [PubMed] [Google Scholar]
  2. Berry J. N., Chakravarty R. N., Gupta H. D., Malik K. Prevalence of diabetes mellitus in a north Indian town. Indian J Med Res. 1966 Nov;54(11):1025–1047. [PubMed] [Google Scholar]
  3. Blacket R. B., Leelarthaepin B., Palmer A. J., Woodhill J. M. Coronary heart disease in young men: a study of seventy patients with a critical review of etiological factors. Aust N Z J Med. 1973 Feb;3(1):39–62. doi: 10.1111/j.1445-5994.1973.tb03956.x. [DOI] [PubMed] [Google Scholar]
  4. Carlson L. A., Böttiger L. E. Ischaemic heart-disease in relation to fasting values of plasma triglycerides and cholesterol. Stockholm prospective study. Lancet. 1972 Apr 22;1(7756):865–868. doi: 10.1016/s0140-6736(72)90738-6. [DOI] [PubMed] [Google Scholar]
  5. DOLL R., HILL A. B. Lung cancer and other causes of death in relation to smoking; a second report on the mortality of British doctors. Br Med J. 1956 Nov 10;2(5001):1071–1081. doi: 10.1136/bmj.2.5001.1071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. DOYLE J. T., DAWBER T. R., KANNEL W. B., HESLIN A. S., KAHN H. A. Cigarette smoking and coronary heart disease. Combined experience of the Albany and Framingham studies. N Engl J Med. 1962 Apr 19;266:796–801. doi: 10.1056/nejm196204192661602. [DOI] [PubMed] [Google Scholar]
  7. DOYLE J. T., DAWBER T. R., KANNEL W. B., KINCH S. H., KAHN H. A. THE RELATIONSHIP OF CIGARETTE SMOKING TO CORONARY HEART DISEASE; THE SECOND REPORT OF THE COMBINED EXPERIENCE OF THE ALBANY, NY. AND FRAMINGHAM, MASS. STUDIES. JAMA. 1964 Dec 7;190:886–890. [PubMed] [Google Scholar]
  8. Epstein F. H. Coronary heart disease epidemiology revisited. Clinical and community aspects. Circulation. 1973 Jul;48(1):185–189. doi: 10.1161/01.cir.48.1.185. [DOI] [PubMed] [Google Scholar]
  9. Epstein F. H., Ostrander L. D., Jr Detection of individual susceptibility toward coronary disease. Prog Cardiovasc Dis. 1971 Jan;13(4):324–342. doi: 10.1016/s0033-0620(71)80010-5. [DOI] [PubMed] [Google Scholar]
  10. Epstein F. H. The epidemiology of coronary heart disease. A review. J Chronic Dis. 1965 Aug;18(8):735–774. doi: 10.1016/0021-9681(65)90017-2. [DOI] [PubMed] [Google Scholar]
  11. Goldstein J. L., Hazzard W. R., Schrott H. G., Bierman E. L., Motulsky A. G. Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. J Clin Invest. 1973 Jul;52(7):1533–1543. doi: 10.1172/JCI107331. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hall A. P. Correlations among hyperuricemia, hypercholesterolemia, coronary disease and hypertension. Arthritis Rheum. 1965 Oct;8(5):846–852. doi: 10.1002/art.1780080449. [DOI] [PubMed] [Google Scholar]
  13. Kannel W. B., Castelli W. P., Gordon T., McNamara P. M. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med. 1971 Jan;74(1):1–12. doi: 10.7326/0003-4819-74-1-1. [DOI] [PubMed] [Google Scholar]
  14. Kannel W. B., Castelli W. P., McNamara P. M. The coronary profile: 12-year follow-up in the Framingham study. J Occup Med. 1967 Dec;9(12):611–619. [PubMed] [Google Scholar]
  15. Keen H., Rose G., Pyke D. A., Boyns D., Chlouverakis C. Blood-sugar and arterial disease. Lancet. 1965 Sep 11;2(7411):505–508. doi: 10.1016/s0140-6736(65)91470-4. [DOI] [PubMed] [Google Scholar]
  16. Ostrander L. D., Jr, Neff B. J., Block W. D., Francis T., Jr, Epstein F. H. Hyperglycemia and hypertriglyceridemia among persons with coronary heart disease. Ann Intern Med. 1967 Jul;67(1):34–41. doi: 10.7326/0003-4819-67-1-34. [DOI] [PubMed] [Google Scholar]
  17. Page I. H., Berrettoni J. N., Butkus A., Sones F. M., Jr Prediction of coronary heart disease based on clinical suspicion, age, total cholesterol, and triglyceride. Circulation. 1970 Oct;42(4):625–645. doi: 10.1161/01.cir.42.4.625. [DOI] [PubMed] [Google Scholar]
  18. REAVEN G., CALCIANO A., CODY R., LUCAS C., MILLER R. CARBOHYDRATE INTOLERANCE AND HYPERLIPEMIA IN PATIENTS WITH MYOCARDIAL INFARCTION WITHOUT KNOWN DIABETES MELLITUS. J Clin Endocrinol Metab. 1963 Oct;23:1013–1023. doi: 10.1210/jcem-23-10-1013. [DOI] [PubMed] [Google Scholar]
  19. Truett J., Cornfield J., Kannel W. A multivariate analysis of the risk of coronary heart disease in Framingham. J Chronic Dis. 1967 Jul;20(7):511–524. doi: 10.1016/0021-9681(67)90082-3. [DOI] [PubMed] [Google Scholar]

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