Abstract
An electrocardiographic study of the families of two children with isolated complete right bundle-branch block is presented. Several cases of classical complete right bundle-branch block were disclosed (17/69 and 3/22 respectively) in three generations of the two families. Personal interviews and parish registers showed that the two families were related, being descendants 8 generations back from a glass-blower who has emigrated to Sweden in the eighteenth century. It is concluded that complete right bundle-branch block can be an autosomal, genetic anomaly which is inherited dominantly but with reduced penetrance and/or expressivity.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COMBRINK J. M., DAVIS W. H., SNYMAN H. W. Familial bundle branch block. Am Heart J. 1962 Sep;64:397–400. doi: 10.1016/0002-8703(62)90156-4. [DOI] [PubMed] [Google Scholar]
- GAZES P. C., CULLER R. M., TABER E., KELLY T. E. CONGENITAL FAMILIAL CARDIAC CONDUCTION DEFECTS. Circulation. 1965 Jul;32:32–34. doi: 10.1161/01.cir.32.1.32. [DOI] [PubMed] [Google Scholar]
- HISS R. G., LAMB L. E. Electrocardiographic findings in 122,043 individuals. Circulation. 1962 Jun;25:947–961. doi: 10.1161/01.cir.25.6.947. [DOI] [PubMed] [Google Scholar]
- MOSETTI A. Blocco di branca familiare; considerazioni etiopatogenetiche. Folia Cardiol. 1954 Dec 31;13(6):527–535. [PubMed] [Google Scholar]
- OSTRANDER L. D., Jr BUNDLE-BRANCH BLOCK: AN EPIDEMIOLOGIC STUDY. Circulation. 1964 Dec;30:872–881. doi: 10.1161/01.cir.30.6.872. [DOI] [PubMed] [Google Scholar]
- Schaal S. F., Seidensticker J., Goodman R., Wooley C. F. Familial right bundle-branch block, left axis deviation, complete heart block, and early death. A heritable disorder of cardiac conduction. Ann Intern Med. 1973 Jul;79(1):63–66. doi: 10.7326/0003-4819-79-1-63. [DOI] [PubMed] [Google Scholar]
- Simonsen E. E., Madsen E. G. Four cases of right-sided bundle-branch block and one case of atrioventricular block in three generations of a family. Br Heart J. 1970 Jul;32(4):501–504. doi: 10.1136/hrt.32.4.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRIVELLA P., CHELLA S. [Familial and congenital right branch block]. Minerva Cardioangiol. 1960 Apr;8:186–191. [PubMed] [Google Scholar]