Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1975 Jul;37(7):775–778. doi: 10.1136/hrt.37.7.775

Cerebral and cardiac toxicity of a small dose of lignocaine.

H O Klein, I Jutrin, E Kaplinsky
PMCID: PMC482873  PMID: 808233

Abstract

A patient is reported in whom an intravenous bolus injection of 50 mg lignocaine produced extreme sinus bradycardia (rate 14 to 20/min). Only 2 patients with such a response to a similarly small dose have been previously reported, but these reports indicate clearly that careful electrocardiographic monitoring is advisable when lignocaine is administered.

Full text

PDF
775

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chalmers J. P., Wurtman R. J. The fate of intracisternally administered norepinephrine-3H in the brain and spinal cord of the rabbit. J Pharmacol Exp Ther. 1971 Jul;178(1):8–19. [PubMed] [Google Scholar]
  2. Cheng T. O., Wadhwa K. Sinus standstill following intravenous lidocaine administration. JAMA. 1973 Feb 12;223(7):790–792. [PubMed] [Google Scholar]
  3. Flensted-Jensen E., Sandoe E. Lidocaine as an antiarrhythmic Experience in 68 patients. Acta Med Scand. 1969 Apr;185(4):297–302. [PubMed] [Google Scholar]
  4. Jeresaty R. M., Kahn A. H., Landry A. B., Jr Sinoatrial arrest due to lidocaine in a patient receiving guinidine. Chest. 1972 Jun;61(7):683–685. doi: 10.1378/chest.61.7.683. [DOI] [PubMed] [Google Scholar]
  5. Lieberman N. A., Harris R. S., Katz R. I., Lipschutz H. M., Dolgin M., Fisher V. J. The effects of lidocaine on the electrical and mechanical activity of the heart. Am J Cardiol. 1968 Sep;22(3):375–380. doi: 10.1016/0002-9149(68)90122-7. [DOI] [PubMed] [Google Scholar]
  6. Parameswaran R., Kahn D., Monheit R., Goldberg H. Sinus bradycardia due to lidocaine: clinical-electrophysiologic correlations. J Electrocardiol. 1974 Feb;7(1):75–78. doi: 10.1016/s0022-0736(74)80012-9. [DOI] [PubMed] [Google Scholar]
  7. Rydén L., Cullhed I., Wasir H. Effect of lignocaine on heart rate in patients with sinus bradycardia associated with proven or suspected acute myocardial infarction. Cardiovasc Res. 1972 Nov;6(6):664–670. doi: 10.1093/cvr/6.6.664. [DOI] [PubMed] [Google Scholar]
  8. Zelis R. How benign is lidocaine? Chest. 1972 Jun;61(7):599–600. doi: 10.1378/chest.61.7.599. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES