Skip to main content
PMC home page
British Heart Journal logoLink to British Heart Journal
. 1977 Mar;39(3):255–259. doi: 10.1136/hrt.39.3.255

Changes in systolic time intervals during treatment of diabetes mellitus.

C A Sykes, A D Wright, J M Malins, B L Pentecost
PMCID: PMC483229  PMID: 849385

Abstract

The cardiovascular response to the control of diabetes by sulphonylurea drugs has been investigated using systolic time intervals in a group of 19 diabetics. Before treatment a significantly greater heart rate and shortening of QS2 interval and left ventricular ejection time index were encountered among the more hyperglycaemic diabetic patients requiring drug therapy while all diabetics had a reduction of pre-ejection period index. There was a gradual return of resting heart rate and systolic time intervals to control values along with the fall in plasma sugar concentration during treatment. A likely explanation of the findings is that uncontrolled diabetics, particularly those more severely affected, are subjected to an increased adrenergic stimulus to the cardiovascular system which disappears with therapy. There is no evidence of positive inotropic action of sulphonylurea drugs in this study.

Full text

PDF
255

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAUNWALD E., SARNOFF S. J., STAINSBY W. N. Determinants of duration and mean rate of ventricular ejection. Circ Res. 1958 May;6(3):319–325. doi: 10.1161/01.res.6.3.319. [DOI] [PubMed] [Google Scholar]
  2. Christensen N. J. Plasma norepinephrine and epinephrine in untreated diabetics, during fasting and after insulin administration. Diabetes. 1974 Jan;23(1):1–8. doi: 10.2337/diab.23.1.1. [DOI] [PubMed] [Google Scholar]
  3. Crass M. F., 3rd, Spanheimer R. G., Stone D. B., Brown R. J., 2nd Tolbutamide-induced inotropic responses in the perfused working heart: effects of albumin. Proc Soc Exp Biol Med. 1973 Mar;142(3):861–866. doi: 10.3181/00379727-142-37133. [DOI] [PubMed] [Google Scholar]
  4. Crockett S. E., Marsh D., Lewis R. P., Tzagournis M. Lack of cardiac inotropic effect of tolbutamide in intact man. Metabolism. 1974 Aug;23(8):763–769. doi: 10.1016/0026-0495(74)90008-0. [DOI] [PubMed] [Google Scholar]
  5. Ghose J. C., Mitra S. K., Chhetri M. K. Systolic time intervals in the differential diagnosis of constrictive pericarditis and cardiomyopathy. Br Heart J. 1976 Jan;38(1):47–50. doi: 10.1136/hrt.38.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Harris W. S., Schoenfeld C. D., Weissler A. M. Effects of adrenergic receptor activation and blockade on the systolic preejection period, heart rate, and arterial pressure in man. J Clin Invest. 1967 Nov;46(11):1704–1714. doi: 10.1172/JCI105661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Khullar S., Lewis R. P. Usefulness of systolic time intervals in differential diagnosis of constrictive pericarditis and restrictive cardiomyopathy. Br Heart J. 1976 Jan;38(1):43–46. doi: 10.1136/hrt.38.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lasseter K. C., Levey G. S., Palmer R. F., McCarthy J. S. The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts. J Clin Invest. 1972 Sep;51(9):2429–2434. doi: 10.1172/JCI107056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lewis R. P., Boudoulas H., Forester W. F., Weissler A. M. Shortening of electromechanical systole as a manifestation of excessive adrenergic stimulation in acute myocardial infarction. Circulation. 1972 Nov;46(5):856–862. doi: 10.1161/01.cir.46.5.856. [DOI] [PubMed] [Google Scholar]
  10. Martin C. E., Shaver J. A., Thompson M. E., Reddy P. S., Leonard J. J. Direct correlation of external systolic time intervals with internal indices of left ventricular function in man. Circulation. 1971 Sep;44(3):419–431. doi: 10.1161/01.cir.44.3.419. [DOI] [PubMed] [Google Scholar]
  11. Meinert C. L., Knatterud G. L., Prout T. E., Klimt C. R. A study of the effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. II. Mortality results. Diabetes. 1970;19(Suppl):789–830. [PubMed] [Google Scholar]
  12. Palmer R. F., Lasseter K. C., McCarthy J. Tolbutamide: an inotropic effect on rabbit atria. Lancet. 1971 Mar 20;1(7699):604–604. doi: 10.1016/s0140-6736(71)91208-6. [DOI] [PubMed] [Google Scholar]
  13. RAAB W., DE PAULA E SILVA P., STARCHESKA Y. K. Adrenergic and cholinergic influences on the dynamic cycle of the normal human heart. Cardiologia. 1958;33(5):350–364. doi: 10.1159/000166357. [DOI] [PubMed] [Google Scholar]
  14. Shapiro W., Narahara K., Taubert K. Relationship of plasma digitoxin and digoxin to cardiac response following intravenous digitalization in man. Circulation. 1970 Dec;42(6):1065–1072. doi: 10.1161/01.cir.42.6.1065. [DOI] [PubMed] [Google Scholar]
  15. Shaver J. A., Kroetz F. W., Leonard J. J., Paley H. W. The effect of steady-state increases in systemic arterial pressure on the duration of left ventricular ejection time. J Clin Invest. 1968 Jan;47(1):217–230. doi: 10.1172/JCI105711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. WEISSLER A. M., KAMEN A. R., BORNSTEIN R. S., SCHOENFELD C. D., COHEN S. THE EFFECT OF DESLANOSIDE ON THE DURATION OF THE PHASES OF VENTRICULAR SYSTOLE IN MAN. Am J Cardiol. 1965 Feb;15:153–161. doi: 10.1016/0002-9149(65)90449-2. [DOI] [PubMed] [Google Scholar]
  17. Weissler A. M., Harris W. S., Schoenfeld C. D. Bedside technics for the evaluation of ventricular function in man. Am J Cardiol. 1969 Apr;23(4):577–583. doi: 10.1016/0002-9149(69)90012-5. [DOI] [PubMed] [Google Scholar]
  18. Young J. L., Jr, Burr I. M., Perry J. M., Nelson J. H., Nies A. S. Inotropic effects of tolbutamide in man. Am Heart J. 1975 Feb;89(2):189–194. doi: 10.1016/0002-8703(75)90045-9. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES