Table 2.
Compound | 5-HT2C | 5-HT2A | 5-HT2B | Ref. | |||
---|---|---|---|---|---|---|---|
EC50 [nm] | Emax [%] | EC50 [nm] | Emax [%] | EC50 [nm] | Emax [%] | ||
9 | 2697 | 109 | NA | – | >5000 | 29 | [21] |
(±)-10 | 13 | 96 | 1399 | 74 | 85 | 93 | [21] |
(+)-10 (1S, 2S) | 5.2 | 108 | 1396 | 79 | 37 | 111 | [21] |
11 | 4.8 | 95 | 585 | 86 | 65 | 93 | [21] |
13 (X=F) | 21 | 71 | 894 | 28 | 289 | 21 | [22] |
14 (X=OH) | 9.3 | 70 | 372 | 18 | NA | – | [22] |
15 (X=H) | 55 | 61 | NA | – | NA | – | [23] |
16 | 4.2 | 87 | 374 | 56 | NA | – | [24] |
17 | 3.4 | 89 | 359 | 76 | NA | – | [24] |
NA: no activity at 10 μm; – not applicable.