Skip to main content
British Heart Journal logoLink to British Heart Journal
. 1977 Jul;39(7):721–725. doi: 10.1136/hrt.39.7.721

Haemodynamic effects of salbutamol and nitroprusside after cardiac surgery.

P A Poole-Wilson, G Lewis, T Angerpointer, A D Malcolm, B T Williams
PMCID: PMC483308  PMID: 328027

Abstract

The haemodynamic effects of a continuous intravenous infusion of salbutamol (15 to 30 microgram/min) and nitroprusside (50 to 100 microgram/min) were compared in 9 patients after cardiac surgical operations. The mean falls in left atrial pressure and systemic vascular resistance were similar with the two drugs but salbutamol caused a greater increase in heart rate, maximum acceleration of aortic blood flow, and maximum rate of change of left ventricular power. Because these differences would cause greater myocardial oxygen consumption with salbutamol and because the infusion of salbutamol is less easily controlled, nitroprusside is the preferred drug after cardiac operations.

Full text

PDF
721

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bolen J. L., Lopes M. G., Harrison D. C., Alderman E. L. Analysis of left ventricular function in response to afterload changes in patients with mitral stenosis. Circulation. 1975 Nov;52(5):894–900. doi: 10.1161/01.cir.52.5.894. [DOI] [PubMed] [Google Scholar]
  2. Bourne P. R., Williams B. T. A cardiac monitor combining flow and pressure measurement. Biomed Eng. 1975 Dec;10(12):453–455. [PubMed] [Google Scholar]
  3. Braunwald E. Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol. 1971 Apr;27(4):416–432. doi: 10.1016/0002-9149(71)90439-5. [DOI] [PubMed] [Google Scholar]
  4. Chatterjee K., Parmley W. W., Ganz W., Forrester J., Walinsky P., Crexells C., Swan H. J. Hemodynamic and metabolic responses to vasodilator therapy in acute myocardial infarction. Circulation. 1973 Dec;48(6):1183–1193. doi: 10.1161/01.cir.48.6.1183. [DOI] [PubMed] [Google Scholar]
  5. Gibson D. G., Coltart D. J. Haemodynamic effects of intravenous salbutamol in patients with mitral valve disease: comparison with isoprenaline and atropine. Postgrad Med J. 1971 Mar;47(Suppl):40–44. [PubMed] [Google Scholar]
  6. Goldstein R. E., Stinson E. B., Scherer J. L., Seningen R. P., Grehl T. M., Epstein S. E. Intraoperative coronary collateral function in patients with coronary occlusive disease. Nitroglycerin responsiveness and angiographic correlations. Circulation. 1974 Feb;49(2):298–308. doi: 10.1161/01.cir.49.2.298. [DOI] [PubMed] [Google Scholar]
  7. Goodman D. J., Rossen R. M., Holloway E. L., Alderman E. L., Harrison D. C. Effect of nitroprusside on left ventricular dynamics in mitral regurgitation. Circulation. 1974 Nov;50(5):1025–1032. doi: 10.1161/01.cir.50.5.1025. [DOI] [PubMed] [Google Scholar]
  8. Guiha N. H., Cohn J. N., Mikulic E., Franciosa J. A., Limas C. J. Treatment of refractory heart failure with infusion of nitroprusside. N Engl J Med. 1974 Sep 19;291(12):587–592. doi: 10.1056/NEJM197409192911201. [DOI] [PubMed] [Google Scholar]
  9. Lal S., Savidge R. S., Davies D. M., Ali M. M., Soni V. Intravenous salbutamol and cardiogenic shock. Lancet. 1972 Apr 15;1(7755):853–854. doi: 10.1016/s0140-6736(72)90846-x. [DOI] [PubMed] [Google Scholar]
  10. Leitch A. G., Clancy L. J., Costello J. F., Flenley D. C. Effect of intravenous infusion of salbutamol on ventilatory response to carbon dioxide and hypoxia and on heart rate and plasma potassium in normal men. Br Med J. 1976 Feb 14;1(6006):365–367. doi: 10.1136/bmj.1.6006.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Maroko P. R., Kjekshus J. K., Sobel B. E., Watanabe T., Covell J. W., Ross J., Jr, Braunwald E. Factors influencing infarct size following experimental coronary artery occlusions. Circulation. 1971 Jan;43(1):67–82. doi: 10.1161/01.cir.43.1.67. [DOI] [PubMed] [Google Scholar]
  12. Miller R. R., Vismara L. A., Zelis R., Amsterdam E. A., Mason D. T. Clinical use of sodium nitroprusside in chronic ischemic heart disease. Effects on peripheral vascular resistance and venous tone and on ventricular volume, pump and mechanical performance. Circulation. 1975 Feb;51(2):328–336. doi: 10.1161/01.cir.51.2.328. [DOI] [PubMed] [Google Scholar]
  13. Rossen R. M., Alderman E. L., Harrison D. C. Circulatory response to vasodilator therapy in congestive cardiomyopathy. Br Heart J. 1976 Jul;38(7):695–700. doi: 10.1136/hrt.38.7.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Stein P. D., Sabbah H. N. Ventricular performance measured during ejection: Studies in patients of the rate of change of ventricular power. Am Heart J. 1976 May;91(5):599–606. doi: 10.1016/s0002-8703(76)80145-7. [DOI] [PubMed] [Google Scholar]
  15. Warrell D. A., Robertson D. G., Howes J. N., Conolly M. E., Paterson J. W., Beilin L. J., Dollery C. T. Comparison of cardiorespiratory effects of isoprenaline and salbutamol in patients with bronchial asthma. Br Med J. 1970 Jan 10;1(5688):65–70. [PMC free article] [PubMed] [Google Scholar]
  16. Williams B. T., Sancho-Fornos S., Clarke D. B., Abrams L. D., Schenk W. G., Jr, Barefoot C. A. The Williams-Barefoot extractable blood flow probe. Design, transducer characteristics, and clinical application in cardiac surgery. J Thorac Cardiovasc Surg. 1972 Jun;63(6):917–921. [PubMed] [Google Scholar]
  17. Wyse S. D., Gibson D. G., Branthwaite M. A. Haemodynamic effects of salbutamol in patients needing circulatory support after open-heart surgery. Br Med J. 1974 Aug 24;3(5929):502–503. doi: 10.1136/bmj.3.5929.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Yacoub M. H., Boyland E. Cardiovascular effects of intravenous salbutamol after open heart operations. Lancet. 1973 Jun 2;1(7814):1260–1261. doi: 10.1016/s0140-6736(73)90583-7. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES