Abstract
Current practices of intravenous lignocaine administration may result in a significant drop in blood level between the peak serum level from the initial bolus and the subsequent steady state from the constant infusion. This can cause a significant interval when plasma lignocaine levels are less than therapeutic, and ventricular ectopy may occur. To eliminate this subtherapeutic interval, a new therapeutic approach was devised. Seven patients were studied who had no evidence of congestive heart failure or liver disease. Lignocaine was infused at a rate of 25 mg/min; infusion dosages were selected by patient weight. The above therapeutic regimen eliminated the subtherapeutic hiatus and did not result in clinical toxicity. Therefore, this new infusion technique has significant clinical advantages in patients who require therapy with intravenous lignocaine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alderman E. L., Kerber R. E., Harrison D. C. Evaluation of lidocaine resistance in man using intermittent large-dose infusion techniques. Am J Cardiol. 1974 Sep;34(3):342–349. doi: 10.1016/0002-9149(74)90037-x. [DOI] [PubMed] [Google Scholar]
- Aps C., Bell J. A., Jenkins B. S., Poole-Wilson P. A., Reynolds F. Logical approach to lignocaine therapy. Br Med J. 1976 Jan 3;1(6000):13–15. doi: 10.1136/bmj.1.6000.13. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bassan M. M., Weinstein S. R., Mandel W. J. Use of lidocaine by continuous infusion. Am Heart J. 1974 Mar;87(3):302–303. doi: 10.1016/0002-8703(74)90069-6. [DOI] [PubMed] [Google Scholar]
- Boyes R. N., Scott D. B., Jebson P. J., Godman M. J., Julian D. G. Pharmacokinetics of lidocaine in man. Clin Pharmacol Ther. 1971 Jan-Feb;12(1):105–116. doi: 10.1002/cpt1971121105. [DOI] [PubMed] [Google Scholar]
- Collinsworth K. A., Kalman S. M., Harrison D. C. The clinical pharmacology of lidocaine as an antiarrhythymic drug. Circulation. 1974 Dec;50(6):1217–1230. doi: 10.1161/01.cir.50.6.1217. [DOI] [PubMed] [Google Scholar]
- Gianelly R., von der Groeben J. O., Spivack A. P., Harrison D. C. Effect of lidocaine on ventricular arrhythmias in patients with coronary heart disease. N Engl J Med. 1967 Dec 7;277(23):1215–1219. doi: 10.1056/NEJM196712072772301. [DOI] [PubMed] [Google Scholar]
- Greenblatt D. J., Bolognini V., Koch-Weser J., Harmatz J. S. Pharmacokinetic approach to the clinical use of lidocaine intravenously. JAMA. 1976 Jul 19;236(3):273–277. [PubMed] [Google Scholar]
- Keenaghan J. B. The determination of lidocaine and prilocaine in whole blood by gas chromatography. Anesthesiology. 1968 Jan-Feb;29(1):110–112. doi: 10.1097/00000542-196801000-00029. [DOI] [PubMed] [Google Scholar]
- Lie K. I., Wellens H. J., van Capelle F. J., Durrer D. Lidocaine in the prevention of primary ventricular fibrillation. A double-blind, randomized study of 212 consecutive patients. N Engl J Med. 1974 Dec 19;291(25):1324–1326. doi: 10.1056/NEJM197412192912504. [DOI] [PubMed] [Google Scholar]
- Rowland M., Thomson P. D., Guichard A., Melmon K. L. Disposition kinetics of lidocaine in normal subjects. Ann N Y Acad Sci. 1971 Jul 6;179:383–398. doi: 10.1111/j.1749-6632.1971.tb46915.x. [DOI] [PubMed] [Google Scholar]
- Stenson R. E., Constantino R. T., Harrison D. C. Interrelationships of hepatic blood flow, cardiac output, and blood levels of lidocaine in man. Circulation. 1971 Feb;43(2):205–211. doi: 10.1161/01.cir.43.2.205. [DOI] [PubMed] [Google Scholar]
- Thomson P. D., Melmon K. L., Richardson J. A., Cohn K., Steinbrunn W., Cudihee R., Rowland M. Lidocaine pharmacokinetics in advanced heart failure, liver disease, and renal failure in humans. Ann Intern Med. 1973 Apr;78(4):499–508. doi: 10.7326/0003-4819-78-4-499. [DOI] [PubMed] [Google Scholar]