Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1978 Jun;40(6):602–607. doi: 10.1136/hrt.40.6.602

Long-term haemodynamic evaluation of aortic pericardial xenograft.

A P Tandon, D R Smith, W Whitaker, M I Ionescu
PMCID: PMC483455  PMID: 656233

Abstract

Haemodynamic studies were performed in 30 patients at a mean interval of 43.4 (range 27 to 59) months after aortic valve replacements with pericardial xenografts. Five valve sizes--19, 21, 23, 25, and 27 mm annulus diameter--were used. Of these 30 patients, 16 had preoperative haemodynamic investigations. Comparison of the pre- and postoperative data showed a marginal but significant increase in cardiac output (P less than 0.05). There was a significant reduction in the pulmonary wedge and left ventricular end-diastolic pressures at rest and on exercise (P less than 0.05 and P less than 0.01). At the postoperative study the mean peak systolic gradient was 8.3 mmHg at rest and 12.3 mmHg on exercise in patients with the smallest xenograft inserted (19 mm) and decreased with each corresponding increase in graft size, so that across the 27 mm graft it was hardly measurable. The calculated xenograft surface area ranged from 1.1 to 2.1 cm2 at rest and 1.3 to 2.4 cm2 during exercise. Aortic root angiography showed competent valves in all 30 patients, but a grade 1 to 2 perivalvular leak was shown in 8 patients. This long-term study has indicated significant circulatory improvement and very small transvalvular gradients in patients with aortic pericardial xenografts.

Full text

PDF
602

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson R. P., Bonchek L. I., Grunkemeier G. L., Lambert L. E., Starr A. The analysis and presentation of surgical results by actuarial methods. J Surg Res. 1974 Mar;16(3):224–230. doi: 10.1016/0022-4804(74)90035-3. [DOI] [PubMed] [Google Scholar]
  2. Björk V. O. A new central-flow tilting disc valve prosthesis. One year's clinical experience with 103 patients. J Thorac Cardiovasc Surg. 1970 Sep;60(3):355–374. [PubMed] [Google Scholar]
  3. Björk V. O., Henze A. Encapsulation of the Björk-Shiley aortic disc valve prosthesis caused by the lack of anticoagulant treatment. Scand J Thorac Cardiovasc Surg. 1973;7(1):17–20. doi: 10.3109/14017437309139160. [DOI] [PubMed] [Google Scholar]
  4. Björk V. O., Henze A., Holmgren A. Five years' experience with the Björk-Shiley tilting-disc valve in isolated aortic valvular disease. J Thorac Cardiovasc Surg. 1974 Sep;68(3):393–404. [PubMed] [Google Scholar]
  5. Björk V. O., Holmgren A., Olin C., Ovenfors C. O. Clinical and haemodynamic results of aortic valve replacement with the Björk-Shiley tilting disc valve prosthesis. Scand J Thorac Cardiovasc Surg. 1971;5(3):177–191. [PubMed] [Google Scholar]
  6. Blank R. H., Pupello D. F., Bessone L. N., Harrison E. E., Sbar S. Method of managing the small aortic annulus during valve replacement. Ann Thorac Surg. 1976 Oct;22(4):356–361. doi: 10.1016/s0003-4975(10)64967-3. [DOI] [PubMed] [Google Scholar]
  7. Blank R. H., Pupello D. F., Bessone L. N., Harrison E. E., Sbar S. Method of managing the small aortic annulus during valve replacement. Ann Thorac Surg. 1976 Oct;22(4):356–361. doi: 10.1016/s0003-4975(10)64967-3. [DOI] [PubMed] [Google Scholar]
  8. Brandt P. W., Roche A. H., Barratt-Boyes B. G., Lowe J. B. Radiology of homograft aortic valves. Thorax. 1969 Mar;24(2):129–141. doi: 10.1136/thx.24.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bristow J. D., Kremkau E. L. Hemodynamic changes after valve replacement with Starr-Edwards prostheses. Am J Cardiol. 1975 May;35(5):716–724. doi: 10.1016/0002-9149(75)90064-8. [DOI] [PubMed] [Google Scholar]
  10. Cohn L. H., Sanders J. H., Jr, Collins J. J., Jr Aortic valve replacement with the Hancock porcine xenograft. Ann Thorac Surg. 1976 Sep;22(3):221–227. doi: 10.1016/s0003-4975(10)64906-5. [DOI] [PubMed] [Google Scholar]
  11. Najafi H., Ostermiller W. E., Jr, Javid H., Dye W. S., Hunter J. A., Julian O. C. Narrow aortic root complicating aortic valve replacement. Arch Surg. 1969 Dec;99(6):690–694. doi: 10.1001/archsurg.1969.01340180014003. [DOI] [PubMed] [Google Scholar]
  12. Sigwart U., Schmidt H., Gleichmann U., Borst H. G. In vivo evaluation of the Lillehei-Kaster heart valve prosthesis. Ann Thorac Surg. 1976 Sep;22(3):213–220. doi: 10.1016/s0003-4975(10)64905-3. [DOI] [PubMed] [Google Scholar]
  13. Tandon A. P., Smith D. R., Mary D. A., Ionescu M. I. Sequential hemodynamic studies in patients having aortic valve replacement with the Ionescu-Shiley pericardial xenograft. Ann Thorac Surg. 1977 Aug;24(2):149–155. doi: 10.1016/s0003-4975(10)63724-1. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES