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. 1978 Aug;40(8):825–831. doi: 10.1136/hrt.40.8.825

A morphometric study of regional variation in lung structure in infants with pulmonary hypertension and congenital cardiac defect. A justification of lung biopsy.

S G Haworth, L Reid
PMCID: PMC483494  PMID: 687483

Abstract

The structure of the pulmonary circulation throughout the lung has been analysed by morphometric techniques in 4 infants dying with ventricular septal defect and pulmonary hypertension. Failure of the intra-acinar pulmonary circulation to develop normally is shown by a reduction in arterial size and number, and an increase in muscularity is judged by the degree of medial hypertrophy and by extension of muscle further along the arterial pathway than is normal. For these features, one section of lung tissue, 1 cm square, proved to be representative of the entire pulmonary vascular bed, and also gave satisfactory assessment of lung growth and development. Lung biopsy can help in the clinical management of children with congenital cardiac defects and pulmonary hypertension if, in selecting tissue at biopsy, allowance is made for any regional differences in pulmonary blood flow.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Davies G., Reid L. Growth of the alveoli and pulmonary arteries in childhood. Thorax. 1970 Nov;25(6):669–681. doi: 10.1136/thx.25.6.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HARRISON C. V. IV. The pathology of the pulmonary vessels in pulmonary hypertension. Br J Radiol. 1958 Apr;31(364):217–226. doi: 10.1259/0007-1285-31-364-217. [DOI] [PubMed] [Google Scholar]
  3. HEATH D., BEST P. V. The tunica media of the arteries of the lung in pulmonary hypertension. J Pathol Bacteriol. 1958 Jul;76(1):165–174. doi: 10.1002/path.1700760119. [DOI] [PubMed] [Google Scholar]
  4. Haworth S. G., Sauer U., Bũhlmeyer K., Reid L. Development of the pulmonary circulation in ventricular septal defect: a quantitative structural study. Am J Cardiol. 1977 Nov;40(5):781–788. doi: 10.1016/0002-9149(77)90197-7. [DOI] [PubMed] [Google Scholar]
  5. Hislop A., Reid L. Development of the acinus in the human lung. Thorax. 1974 Jan;29(1):90–94. doi: 10.1136/thx.29.1.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hislop A., Reid L. New findings in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension. Br J Exp Pathol. 1976 Oct;57(5):542–554. [PMC free article] [PubMed] [Google Scholar]
  7. Hislop A., Reid L. New pathological findings in emphysema of childhood. 1. Polyalveolar lobe with emphysema. Thorax. 1970 Nov;25(6):682–690. doi: 10.1136/thx.25.6.682. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hislop A., Reid L. Pulmonary arterial development during childhood: branching pattern and structure. Thorax. 1973 Mar;28(2):129–135. doi: 10.1136/thx.28.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Reid L. The angiogram and pulmonary artery structure and branching (in the normal and with reference to disease). Proc R Soc Med. 1965 Sep;58(9):681–684. doi: 10.1177/003591576505800906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Simons P., Reid L. Muscularity of pulmonary artery branches in the upper and lower lobes of the normal young and aged lung. Br J Dis Chest. 1969 Jan;63(1):38–44. doi: 10.1016/s0007-0971(69)80042-2. [DOI] [PubMed] [Google Scholar]
  11. WAGENVOORT C. A. Vasoconstriction and medial hypertrophy in pulmonary hypertension. Circulation. 1960 Oct;22:535–546. doi: 10.1161/01.cir.22.4.535. [DOI] [PubMed] [Google Scholar]

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