Skip to main content
NCBI home page
British Heart Journal logoLink to British Heart Journal
. 1978 Aug;40(8):874–882. doi: 10.1136/hrt.40.8.874

Use of 129caesium, 99Tcm stannous pyrophosphate, and a combination of the two in the assessment of myocardial infarction.

S Walton, E Kafetzakis, R A Shields, H J Testa, D J Rowlands
PMCID: PMC483502  PMID: 687489

Abstract

Acutely damaged myocardium was shown in 103 patients with suspected acute myocardial infarction using 99Tcm pyp. A significant incidence of false positive and false negative results occurred, 'true' results being defined by standard clinical, electrocardiographic, and enzyme criteria. Localisation of infarction compared reasonably well with standard electrocardiographic criteria but more frequently suggested true posterior involvement. Serial estimates of infarct size may be of value in the recognition of infarct extension during the acute phase. Viable perfused myocardium was shown in 63 patients with a variety of cardiac disorders using 129Cs. The technique gives a reliable indication of anterior infarction but tends to underestimate inferior infarction. There was good correlation with the electrocardiogram with regard to localisation and extent of infarction. Nineteen patients received both isotopes and were included in each of the above groups. The combination permits further assessment of equivocal results Furthermore as 129Cs demonstrates both previous and recent infarction and 99Tcm pyp accumulates only in acutely damaged myocardium it was possible to estimate the extent of previous and recent myocardial damage.

Full text

PDF
874

Images in this article

876Image
on p.876
876Image
on p.876
877Image
on p.877

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmad M., Dubiel J. P., Verdon T. A., Martin R. H. Technetium 99m stannous pyrophosphate myocardial imaging in patients with and without left ventricular aneurysm. Circulation. 1976 May;53(5):833–838. doi: 10.1161/01.cir.53.5.833. [DOI] [PubMed] [Google Scholar]
  2. Bonte F. J., Parkey R. W., Graham K. D., Moore J. G. Distributions of several agents useful in imaging myocardial infarcts. J Nucl Med. 1975 Feb;16(2):132–135. [PubMed] [Google Scholar]
  3. Bonte F. J., Parkey R. W., Graham K. D., Moore J., Stokely E. M. A new method for radionuclide imaging of myocardial infarcts. Radiology. 1974 Feb;110(2):473–474. doi: 10.1148/110.2.473. [DOI] [PubMed] [Google Scholar]
  4. Botvinick E. H., Shames D., Lappin H., Tyberg J. V., Townsend R., Parmley W. W. Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate. Circulation. 1975 Nov;52(5):909–915. doi: 10.1161/01.cir.52.5.909. [DOI] [PubMed] [Google Scholar]
  5. D'Agostino A. N., Chiga M. Mitochondrial mineralization in human myocardium. Am J Clin Pathol. 1970 Jun;53(6):820–824. doi: 10.1093/ajcp/53.6.820. [DOI] [PubMed] [Google Scholar]
  6. Dewanjee M. K., Kahn P. C. Mechanism of localization of 99mTc-labeled pyrophosphate and tetracycline in infarcted myocardium. J Nucl Med. 1976 Jul;17(7):639–646. [PubMed] [Google Scholar]
  7. Donsky M. S., Curry G. C., Parkey R. W., Meyer S. L., Bonte F. J., Platt M. R., Willerson J. T. Unstable angina pectoris. Clinical, angiographic, and myocardial scintigraphic observations. Br Heart J. 1976 Mar;38(3):257–263. doi: 10.1136/hrt.38.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Go R. T., Doty B. D., Chiu C. L., Christie J. H. A new method of diagnosing myocardial contusion in man by radionuclide imaging. Radiology. 1975 Jul;116(1):107–110. doi: 10.1148/116.1.107. [DOI] [PubMed] [Google Scholar]
  9. Janowitz W. R., Serafini A. D. Intense myocardial uptake of 99mTc-diphosphonate in a uremic patient with secondary hyperparathyroidism and pericarditis: case report. J Nucl Med. 1976 Oct;17(10):896–898. [PubMed] [Google Scholar]
  10. Kelly R. J., Cowan R. J., Maynard C. D., Headley R. N., Kahl F. R. Localization of 99mTc-Sn-pyrophosphate in left ventricular aneurysms. J Nucl Med. 1977 Apr;18(4):342–345. [PubMed] [Google Scholar]
  11. Mueller T. M., Marcus M. L., Ehrhardt J. C., Chaudhuri T., Abboud F. M. Limitations of thallium-201 myocardial perfusion scintigrams. Circulation. 1976 Oct;54(4):640–646. doi: 10.1161/01.cir.54.4.640. [DOI] [PubMed] [Google Scholar]
  12. Parkey R. W., Bonte F. J., Meyer S. L., Atkins J. M., Curry G. L., Stokely E. M., Willerson J. T. A new method for radionuclide imaging of acute myocardial infarction in humans. Circulation. 1974 Sep;50(3):540–546. doi: 10.1161/01.cir.50.3.540. [DOI] [PubMed] [Google Scholar]
  13. Parkey R. W., Bonte F. J., Stokely E. M., Lewis S. E., Graham K. D., Buja L. M., Willerson J. T. Acute myocardial infarction imaged with 99mTc-stannous pyrophosphate and 201Tl: a clinical evaluation. J Nucl Med. 1976 Sep;17(9):771–779. [PubMed] [Google Scholar]
  14. Perez L. A., Hayt D. B., Freeman L. M. Localization of myocardial disorders other than infarction with 99mTc-labeled phosphate agents. J Nucl Med. 1976 Apr;17(4):241–246. [PubMed] [Google Scholar]
  15. Phelps M. E., Hoffman E. J., Coleman R. E., Welch M. J., Raichle M. E., Weiss E. S., Sobel B. E., Ter-Pogossian M. M. Tomographic images of blood pool and perfusion in brain and heart. J Nucl Med. 1976 Jul;17(7):603–612. [PubMed] [Google Scholar]
  16. Poe N. D. Comparative myocardial uptake and clearance characteristics of potassium and cesium. J Nucl Med. 1972 Jul;13(7):557–560. [PubMed] [Google Scholar]
  17. Pugh B. R., Buja L. M., Parkey R. W., Poliner L. R., Stokely E. M., Bonte F. J., Willerson J. T. Cardioversion and "false positive" technetium-99m stannous pyrophosphate myocardial scintigrams. Circulation. 1976 Sep;54(3):399–403. doi: 10.1161/01.cir.54.3.399. [DOI] [PubMed] [Google Scholar]
  18. Romhilt D. W., Adolph R. J., Sodd V. J., Levenson N. I., August L. S., Nishiyama H., Berke R. A. Cesium-129 myocardial scintigraphy to detect myocardial infarction. Circulation. 1973 Dec;48(6):1242–1251. doi: 10.1161/01.cir.48.6.1242. [DOI] [PubMed] [Google Scholar]
  19. Rothman M. T., Critchley M., Shail G., Shields R. A., Testa H. J., Rowlands D. J. Proceedings: Myocardial scanning using 129Cs. Br Heart J. 1974 Oct;36(10):1035–1035. [PubMed] [Google Scholar]
  20. Shen A. C., Jennings R. B. Kinetics of calcium accumulation in acute myocardial ischemic injury. Am J Pathol. 1972 Jun;67(3):441–452. [PMC free article] [PubMed] [Google Scholar]
  21. Soin J. S., Burdine J. A., Beal W. Myocardial localization of 99mTc-pyrophosphate without evidence of acute myocardial infarction. J Nucl Med. 1975 Oct;16(10):944–946. [PubMed] [Google Scholar]
  22. Varat M. A., Mercer D. W. Cardiac specific creatine phosphokinase isoenzyme in the diagnosis of acute myocardial infarction. Circulation. 1975 May;51(5):855–859. doi: 10.1161/01.cir.51.5.855. [DOI] [PubMed] [Google Scholar]
  23. Willerson J. T., Parkey R. W., Bonte F. J., Meyer S. L., Atkins J. M., Stokley E. M. Technetium stannous pyrophosphate myocardial scintigrams in patients with chest pain of varying etiology. Circulation. 1975 Jun;51(6):1046–1052. doi: 10.1161/01.cir.51.6.1046. [DOI] [PubMed] [Google Scholar]
  24. Zaret B., DiCola V. C., Donabedian R. K., Puri S., Wolfson S., Freedman G. S., Cohen L. S. Dual radionuclide study of myocardial infarction. Relationships between myocardial uptake of potassium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine phosphokinase depletion. Circulation. 1976 Mar;53(3):422–428. doi: 10.1161/01.cir.53.3.422. [DOI] [PubMed] [Google Scholar]

Articles from British Heart Journal are provided here courtesy of BMJ Publishing Group

RESOURCES