Abstract
The condition of a neonate with severe persistent pulmonary hypertension who became severely hypoxic and acidotic despite intensive conventional treatment improved dramatically after endotracheal administration of tolazoline. This logical mode of administration of vasodilator therapy for this condition has not been reported before. It seemed to be life saving in this case and it warrants further clinical trial.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abu-Osba Y. K., Galal O., Manasra K., Rejjal A. Treatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphate. Arch Dis Child. 1992 Jan;67(1 Spec No):31–35. doi: 10.1136/adc.67.1_spec_no.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Rourke P. P., Crone R. K., Vacanti J. P., Ware J. H., Lillehei C. W., Parad R. B., Epstein M. F. Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study. Pediatrics. 1989 Dec;84(6):957–963. [PubMed] [Google Scholar]
- Stevenson D. K., Kasting D. S., Darnall R. A., Jr, Ariagno R. L., Johnson J. D., Malachowski N., Beets C. L., Sunshine P. Refractory hypoxemia associated with neonatal pulmonary disease: the use and limitations of tolazoline. J Pediatr. 1979 Oct;95(4):595–599. doi: 10.1016/s0022-3476(79)80777-5. [DOI] [PubMed] [Google Scholar]
