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. 1995 Dec;74(6):656–659. doi: 10.1136/hrt.74.6.656

Transient reduction of human left ventricular mass in carnitine depletion induced by antibiotics containing pivalic acid.

K Abrahamsson 1, M Mellander 1, B O Eriksson 1, E Holme 1, U Jodal 1, A Jönsson 1, S Lindstedt 1
PMCID: PMC484124  PMID: 8541173

Abstract

OBJECTIVE--To study the effect of induced carnitine depletion on myocardial structure and function. SUBJECTS AND DESIGN--7 healthy adult volunteers given 1200 mg pivmecillinam per day for 7-8 weeks were studied by echocardiography before and after 7-8 weeks of treatment and a 15 months follow up after the treatment period. SETTING--Teaching hospital. MAIN OUTCOME MEASURES--Carnitine concentration in serum, urine, and muscle and echocardiographic measurements. RESULTS--After 7-8 weeks of treatment the median free serum carnitine concentration was reduced to 7% and the median total muscle carnitine concentration to 46% of the pretreatment levels. The median diastolic interventricular septum thickness decreased by 14% (mean 26%, P = 0.028) and the median left ventricular mass by 10% (mean 20%, P = 0.018). Fifteen months later these dimensions had increased but not completely returned to pretreatment values. CONCLUSIONS--Extended treatment with pivalic acid containing antibiotics causes carnitine depletion which may lead to changes in cardiac structure.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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