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. 1996 Apr;75(4):410–413. doi: 10.1136/hrt.75.4.410

Stability of plasma concentrations of N and C terminal atrial natriuretic peptides at room temperature.

J G Cleland 1, S Ward 1, D Dutka 1, F Habib 1, M Impallomeni 1, I J Morton 1
PMCID: PMC484320  PMID: 8705771

Abstract

BACKGROUND: Plasma concentrations of atrial natriuretic peptide (ANP) are increased in patients with ventricular dysfunction and could have a diagnostic role in heart failure. ANP may be unstable after collection, however, limiting any practical diagnostic role. METHODS: Blood samples were obtained from 18 patients with various conditions. Aliquots were either processed optimally or kept as blood or plasma at room temperature for 6-72 h before processing. RESULTS: Concentrations of C-terminal ANP were lower in specimens kept as blood for 24 and 72 h (mean difference from control -43% and -76%, respectively, (P < 0.001) but N-terminal ANP (extracted) seemed to be stable under all conditions studied (-2% at 24 h and -7% at 72 h, not significant). CONCLUSIONS: N-terminal ANP (extracted) is stable and potentially has a role in the diagnosis of heart failure in routine clinical practice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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