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Aberrant DNA methylation is targeted to ICRs within imprinted domains. Images generated from COBRA analysis of 3 regulatory regions within the Gnas and Dlk1/Gtl2 domains. For each domain, the ICR, a nearby DMR and a nearby promoter were measured. Unmethylated DNA is denoted with a U, while methylated DNA is denoted with an M. The enzymes used to digest each amplicon are presented under the name of each PCR product.
