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Methamphetamine (METH)-treated mice with RESDs have acidophilic neurons in 7 of the brain regions that they are found following seizure-induced neuronal necrosis. The number 1 is CA1, 2 is CA2, 3 is CA3, 4 is hilus, 5 is amygdala, 6 is piriform cortex and 7 is entorhinal cortex. ***p < 0.001 compared to control regions, +++p < 0.001, +p < 0.05 compared to brain regions of mice without SREDs, and ###p < 0.001 compared to control regions.
