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. 1996 Nov;76(3 Suppl 3):28–32. doi: 10.1136/hrt.76.3_suppl_3.28

Is there an internal cardiac renin-angiotensin system?

A H Jan Danser 1, Maarten A D H Schalekamp 1
PMCID: PMC484485  PMID: 8983664

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Admiraal P. J., Danser A. H., Jong M. S., Pieterman H., Derkx F. H., Schalekamp M. A. Regional angiotensin II production in essential hypertension and renal artery stenosis. Hypertension. 1993 Feb;21(2):173–184. doi: 10.1161/01.hyp.21.2.173. [DOI] [PubMed] [Google Scholar]
  2. Admiraal P. J., Derkx F. H., Danser A. H., Pieterman H., Schalekamp M. A. Intrarenal de novo production of angiotensin I in subjects with renal artery stenosis. Hypertension. 1990 Nov;16(5):555–563. doi: 10.1161/01.hyp.16.5.555. [DOI] [PubMed] [Google Scholar]
  3. Admiraal P. J., Derkx F. H., Danser A. H., Pieterman H., Schalekamp M. A. Metabolism and production of angiotensin I in different vascular beds in subjects with hypertension. Hypertension. 1990 Jan;15(1):44–55. doi: 10.1161/01.hyp.15.1.44. [DOI] [PubMed] [Google Scholar]
  4. Brilla C. G., Zhou G., Matsubara L., Weber K. T. Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone. J Mol Cell Cardiol. 1994 Jul;26(7):809–820. doi: 10.1006/jmcc.1994.1098. [DOI] [PubMed] [Google Scholar]
  5. Campbell D. J., Kladis A., Duncan A. M. Nephrectomy, converting enzyme inhibition, and angiotensin peptides. Hypertension. 1993 Oct;22(4):513–522. doi: 10.1161/01.hyp.22.4.513. [DOI] [PubMed] [Google Scholar]
  6. Campbell D. J., Valentijn A. J. Identification of vascular renin-binding proteins by chemical cross-linking: inhibition of binding of renin by renin inhibitors. J Hypertens. 1994 Aug;12(8):879–890. [PubMed] [Google Scholar]
  7. Danser A. H., Koning M. M., Admiraal P. J., Derkx F. H., Verdouw P. D., Schalekamp M. A. Metabolism of angiotensin I by different tissues in the intact animal. Am J Physiol. 1992 Aug;263(2 Pt 2):H418–H428. doi: 10.1152/ajpheart.1992.263.2.H418. [DOI] [PubMed] [Google Scholar]
  8. Danser A. H., Koning M. M., Admiraal P. J., Sassen L. M., Derkx F. H., Verdouw P. D., Schalekamp M. A. Production of angiotensins I and II at tissue sites in intact pigs. Am J Physiol. 1992 Aug;263(2 Pt 2):H429–H437. doi: 10.1152/ajpheart.1992.263.2.H429. [DOI] [PubMed] [Google Scholar]
  9. Danser A. H., van Kats J. P., Admiraal P. J., Derkx F. H., Lamers J. M., Verdouw P. D., Saxena P. R., Schalekamp M. A. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension. 1994 Jul;24(1):37–48. doi: 10.1161/01.hyp.24.1.37. [DOI] [PubMed] [Google Scholar]
  10. Dostal D. E., Rothblum K. N., Chernin M. I., Cooper G. R., Baker K. M. Intracardiac detection of angiotensinogen and renin: a localized renin-angiotensin system in neonatal rat heart. Am J Physiol. 1992 Oct;263(4 Pt 1):C838–C850. doi: 10.1152/ajpcell.1992.263.4.C838. [DOI] [PubMed] [Google Scholar]
  11. Ekker M., Tronik D., Rougeon F. Extra-renal transcription of the renin genes in multiple tissues of mice and rats. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5155–5158. doi: 10.1073/pnas.86.13.5155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Falkenhahn M., Franke F., Bohle R. M., Zhu Y. C., Stauss H. M., Bachmann S., Danilov S., Unger T. Cellular distribution of angiotensin-converting enzyme after myocardial infarction. Hypertension. 1995 Feb;25(2):219–226. doi: 10.1161/01.hyp.25.2.219. [DOI] [PubMed] [Google Scholar]
  13. Fei D. T., Scoggins B. A., Tregear G. W., Coghlan J. P. Angiotensin I, II, and III in sheep. A model of angiotensin production and metabolism. Hypertension. 1981 Nov-Dec;3(6):730–737. doi: 10.1161/01.hyp.3.6.730. [DOI] [PubMed] [Google Scholar]
  14. Fujisaki H., Ito H., Hirata Y., Tanaka M., Hata M., Lin M., Adachi S., Akimoto H., Marumo F., Hiroe M. Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression. J Clin Invest. 1995 Aug;96(2):1059–1065. doi: 10.1172/JCI118092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hackenthal E., Hackenthal R., Hilgenfeldt U. Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes. Biochim Biophys Acta. 1978 Feb 10;522(2):574–588. doi: 10.1016/0005-2744(78)90089-x. [DOI] [PubMed] [Google Scholar]
  16. Hiruma M., Kim S., Ikemoto F., Murakami K., Yamamoto K. Fate of recombinant human renin administered exogenously to anesthetized monkeys. Hypertension. 1988 Sep;12(3):317–323. doi: 10.1161/01.hyp.12.3.317. [DOI] [PubMed] [Google Scholar]
  17. Holubarsch C., Hasenfuss G., Schmidt-Schweda S., Knorr A., Pieske B., Ruf T., Fasol R., Just H. Angiotensin I and II exert inotropic effects in atrial but not in ventricular human myocardium. An in vitro study under physiological experimental conditions. Circulation. 1993 Sep;88(3):1228–1237. doi: 10.1161/01.cir.88.3.1228. [DOI] [PubMed] [Google Scholar]
  18. Ishihata A., Endoh M. Species-related differences in inotropic effects of angiotensin II in mammalian ventricular muscle: receptors, subtypes and phosphoinositide hydrolysis. Br J Pharmacol. 1995 Jan;114(2):447–453. doi: 10.1111/j.1476-5381.1995.tb13247.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Iwai N., Inagami T. Quantitative analysis of renin gene expression in extrarenal tissues by polymerase chain reaction method. J Hypertens. 1992 Aug;10(8):717–724. [PubMed] [Google Scholar]
  20. Lindpaintner K., Jin M. W., Niedermaier N., Wilhelm M. J., Ganten D. Cardiac angiotensinogen and its local activation in the isolated perfused beating heart. Circ Res. 1990 Sep;67(3):564–573. doi: 10.1161/01.res.67.3.564. [DOI] [PubMed] [Google Scholar]
  21. Lindpaintner K., Lu W., Neidermajer N., Schieffer B., Just H., Ganten D., Drexler H. Selective activation of cardiac angiotensinogen gene expression in post-infarction ventricular remodeling in the rat. J Mol Cell Cardiol. 1993 Feb;25(2):133–143. doi: 10.1006/jmcc.1993.1017. [DOI] [PubMed] [Google Scholar]
  22. Linz W., Schaper J., Wiemer G., Albus U., Schölkens B. A. Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: a one year study in rats. Br J Pharmacol. 1992 Dec;107(4):970–975. doi: 10.1111/j.1476-5381.1992.tb13393.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Matsubara H., Kanasaki M., Murasawa S., Tsukaguchi Y., Nio Y., Inada M. Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture. J Clin Invest. 1994 Apr;93(4):1592–1601. doi: 10.1172/JCI117139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Miyata S., Haneda T. Hypertrophic growth of cultured neonatal rat heart cells mediated by type 1 angiotensin II receptor. Am J Physiol. 1994 Jun;266(6 Pt 2):H2443–H2451. doi: 10.1152/ajpheart.1994.266.6.H2443. [DOI] [PubMed] [Google Scholar]
  25. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990 Oct;86(4):1343–1346. doi: 10.1172/JCI114844. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Ruzicka M., Yuan B., Leenen F. H. Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats. Circulation. 1994 Jul;90(1):484–491. doi: 10.1161/01.cir.90.1.484. [DOI] [PubMed] [Google Scholar]
  27. Schieffer B., Wirger A., Meybrunn M., Seitz S., Holtz J., Riede U. N., Drexler H. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation. 1994 May;89(5):2273–2282. doi: 10.1161/01.cir.89.5.2273. [DOI] [PubMed] [Google Scholar]
  28. Schunkert H., Dzau V. J., Tang S. S., Hirsch A. T., Apstein C. S., Lorell B. H. Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation. J Clin Invest. 1990 Dec;86(6):1913–1920. doi: 10.1172/JCI114924. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Skeggs L. T., Jr, Dorer F. E. Incorporation of labeled renin into the tissues of the rabbit. Am J Hypertens. 1989 Oct;2(10):768–779. doi: 10.1093/ajh/2.10.768. [DOI] [PubMed] [Google Scholar]
  30. Stoll M., Steckelings U. M., Paul M., Bottari S. P., Metzger R., Unger T. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest. 1995 Feb;95(2):651–657. doi: 10.1172/JCI117710. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Tada M., Takahashi S., Miyano M., Miyake Y. Tissue-specific regulation of renin-binding protein gene expression in rats. J Biochem. 1992 Aug;112(2):175–182. doi: 10.1093/oxfordjournals.jbchem.a123874. [DOI] [PubMed] [Google Scholar]
  32. Yamada H., Fabris B., Allen A. M., Jackson B., Johnston C. I., Mendelsohn A. O. Localization of angiotensin converting enzyme in rat heart. Circ Res. 1991 Jan;68(1):141–149. doi: 10.1161/01.res.68.1.141. [DOI] [PubMed] [Google Scholar]
  33. van Kats J. P., Sassen L. M., Danser A. H., Polak M. P., Soei L. K., Derkx F. H., Schalekamp M. A., Verdouw P. D. Assessment of the role of the renin-angiotensin system in cardiac contractility utilizing the renin inhibitor remikiren. Br J Pharmacol. 1996 Mar;117(5):891–901. doi: 10.1111/j.1476-5381.1996.tb15277.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. von Lutterotti N., Catanzaro D. F., Sealey J. E., Laragh J. H. Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence. Circulation. 1994 Jan;89(1):458–470. doi: 10.1161/01.cir.89.1.458. [DOI] [PubMed] [Google Scholar]

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