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. 1996 Nov;76(3 Suppl 3):45–52. doi: 10.1136/hrt.76.3_suppl_3.45

The renin-angiotensin system and coronary vasomotion

G Ertl 1, K Hu 1, W R Bauer 1, B Bauer 1
PMCID: PMC484488  PMID: 8977364

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Selected References

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  1. Aversano T., Becker L. C. Persistence of coronary vasodilator reserve despite functionally significant flow reduction. Am J Physiol. 1985 Mar;248(3 Pt 2):H403–H411. doi: 10.1152/ajpheart.1985.248.3.H403. [DOI] [PubMed] [Google Scholar]
  2. Bache R. J., Dai X. Z., Baran K. W. Effect of pinacidil on myocardial blood flow in the presence of a coronary artery stenosis. J Cardiovasc Pharmacol. 1990 Apr;15(4):618–625. doi: 10.1097/00005344-199004000-00015. [DOI] [PubMed] [Google Scholar]
  3. Bauer B., Neubauer S., Spindler M., Dürr R., Becker H. H., Ertl G. Interference of angiotensin-converting enzyme inhibition with vasoactive peptides in the coronary circulation of dogs. J Cardiovasc Pharmacol. 1995 May;25(5):756–762. doi: 10.1097/00005344-199505000-00011. [DOI] [PubMed] [Google Scholar]
  4. Bauer W. R., Neubauer S., Obitz G., Ertl G. Interrelation of coronary effects of atrial natriuretic peptide and the renin-angiotensin system in the isolated perfused rat heart. J Mol Cell Cardiol. 1994 Apr;26(4):527–537. doi: 10.1006/jmcc.1994.1063. [DOI] [PubMed] [Google Scholar]
  5. Berdeaux A., Bonhenry C., Giudicelli J. F. Effects of four angiotensin I converting enzyme inhibitors on regional myocardial blood flow and ischemic injury during coronary artery occlusion in dogs. Fundam Clin Pharmacol. 1987;1(3):201–212. doi: 10.1111/j.1472-8206.1987.tb00558.x. [DOI] [PubMed] [Google Scholar]
  6. Bristow J. D., McFalls E. O., Anselone C. G., Pantely G. A. Coronary vasodilator reserve persists despite tachycardia and myocardial ischemia. Am J Physiol. 1987 Aug;253(2 Pt 2):H422–H431. doi: 10.1152/ajpheart.1987.253.2.H422. [DOI] [PubMed] [Google Scholar]
  7. Britton S., Di Salvo J. Effects of angiotensin I and angiotensin II on hindlimb and coronary vascular resistance. Am J Physiol. 1973 Nov;225(5):1226–1231. doi: 10.1152/ajplegacy.1973.225.5.1226. [DOI] [PubMed] [Google Scholar]
  8. Buffington C. W., Feigl E. O. Adrenergic coronary vasoconstriction in the presence of coronary stenosis in the dog. Circ Res. 1981 Mar;48(3):416–423. doi: 10.1161/01.res.48.3.416. [DOI] [PubMed] [Google Scholar]
  9. Cannon R. O., 3rd, Cunnion R. E., Parrillo J. E., Palmeri S. T., Tucker E. E., Schenke W. H., Epstein S. E. Dynamic limitation of coronary vasodilator reserve in patients with dilated cardiomyopathy and chest pain. J Am Coll Cardiol. 1987 Dec;10(6):1190–1200. doi: 10.1016/s0735-1097(87)80118-3. [DOI] [PubMed] [Google Scholar]
  10. Canty J. M., Jr, Klocke F. J. Reduced regional myocardial perfusion in the presence of pharmacologic vasodilator reserve. Circulation. 1985 Feb;71(2):370–377. doi: 10.1161/01.cir.71.2.370. [DOI] [PubMed] [Google Scholar]
  11. Chiu A. T., Roscoe W. A., McCall D. E., Timmermans P. B. Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells. Receptor. 1991;1(3):133–140. [PubMed] [Google Scholar]
  12. Clozel J. P., Hess P., Michael C., Schietinger K., Baumgartner H. R. Inhibition of converting enzyme and neointima formation after vascular injury in rabbits and guinea pigs. Hypertension. 1991 Oct;18(4 Suppl):II55–II59. doi: 10.1161/01.hyp.18.4_suppl.ii55. [DOI] [PubMed] [Google Scholar]
  13. Daly P., Rouleau J. L., Cousineau D., Burgess J. H. Acute effects of captopril on the coronary circulation of patients with hypertension and angina. Am J Med. 1984 May 31;76(5B):111–115. doi: 10.1016/0002-9343(84)90896-9. [DOI] [PubMed] [Google Scholar]
  14. De Marco T., Chatterjee K., Rouleau J. L., Parmley W. W. Abnormal coronary hemodynamics and myocardial energetics in patients with chronic heart failure caused by ischemic heart disease and dilated cardiomyopathy. Am Heart J. 1988 Apr;115(4):809–815. doi: 10.1016/0002-8703(88)90883-6. [DOI] [PubMed] [Google Scholar]
  15. De Marco T., Daly P. A., Liu M., Kayser S., Parmley W. W., Chatterjee K. Enalaprilat, a new parenteral angiotensin-converting enzyme inhibitor: rapid changes in systemic and coronary hemodynamics and humoral profile in chronic heart failure. J Am Coll Cardiol. 1987 May;9(5):1131–1138. doi: 10.1016/s0735-1097(87)80318-2. [DOI] [PubMed] [Google Scholar]
  16. Duncker D. J., Zhang J., Bache R. J. Coronary pressure-flow relation in left ventricular hypertrophy. Importance of changes in back pressure versus changes in minimum resistance. Circ Res. 1993 Mar;72(3):579–587. doi: 10.1161/01.res.72.3.579. [DOI] [PubMed] [Google Scholar]
  17. Ertl G., Alexander R. W., Kloner R. A. Interactions between coronary occlusion and the renin-angiotensin system in the dog. Basic Res Cardiol. 1983 Sep-Oct;78(5):518–533. doi: 10.1007/BF01906463. [DOI] [PubMed] [Google Scholar]
  18. Ertl G. Angiotensin converting enzyme inhibitors in angina and myocardial infarction. What role will they play in the 1990s? Drugs. 1993 Aug;46(2):209–218. doi: 10.2165/00003495-199346020-00001. [DOI] [PubMed] [Google Scholar]
  19. Ertl G., Bauer B., Gaudron P., Kolb M., Kochsiek K. Determinants of coronary effects of atrial natriuretic factor in dogs. Eur J Clin Invest. 1992 Aug;22(8):516–522. doi: 10.1111/j.1365-2362.1992.tb01499.x. [DOI] [PubMed] [Google Scholar]
  20. Ertl G. Coronary vasoconstriction in experimental myocardial ischemia. J Cardiovasc Pharmacol. 1987;9 (Suppl 2):S9–17. doi: 10.1097/00005344-198700002-00004. [DOI] [PubMed] [Google Scholar]
  21. Ertl G., Fuchs M. Alpha-adrenergic vasoconstriction in arterial and arteriolar sections of the canine coronary circulation. Basic Res Cardiol. 1980 Sep-Oct;75(5):600–614. doi: 10.1007/BF01907690. [DOI] [PubMed] [Google Scholar]
  22. Ertl G., Kloner R. A., Alexander R. W., Braunwald E. Limitation of experimental infarct size by an angiotensin-converting enzyme inhibitor. Circulation. 1982 Jan;65(1):40–48. doi: 10.1161/01.cir.65.1.40. [DOI] [PubMed] [Google Scholar]
  23. Ertl G., Meesmann M., Kochsiek K. On the mechanism of renin release during experimental myocardial ischaemia. Eur J Clin Invest. 1985 Dec;15(6):375–381. doi: 10.1111/j.1365-2362.1985.tb00288.x. [DOI] [PubMed] [Google Scholar]
  24. Ertl G., Wichmann J., Steinke E., Lochner W. On the range of alpha-adrenergic regulation of coronary vascular resistance. Basic Res Cardiol. 1979 Sep-Oct;74(5):456–466. doi: 10.1007/BF01907640. [DOI] [PubMed] [Google Scholar]
  25. Faxon D. P., Creager M. A., Halperin J. L., Sussman H. A., Gavras H., Ryan T. J. The effect of angiotensin converting enzyme inhibition of coronary blood flow and hemodynamics in patients without coronary artery disease. Int J Cardiol. 1982;2(2):251–262. doi: 10.1016/0167-5273(82)90040-7. [DOI] [PubMed] [Google Scholar]
  26. Feigl E. O. The paradox of adrenergic coronary vasoconstriction. Circulation. 1987 Oct;76(4):737–745. doi: 10.1161/01.cir.76.4.737. [DOI] [PubMed] [Google Scholar]
  27. Frame L. H., Powell W. J., Jr Progressive perfusion impairment during prolonged low flow myocardial ischemia in dogs. Circ Res. 1976 Aug;39(2):269–276. doi: 10.1161/01.res.39.2.269. [DOI] [PubMed] [Google Scholar]
  28. Friedman L. M., Byington R. P., Capone R. J., Furberg C. D., Goldstein S., Lichstein E. Effect of propranolol in patients with myocardial infarction and ventricular arrhythmia. J Am Coll Cardiol. 1986 Jan;7(1):1–8. doi: 10.1016/s0735-1097(86)80250-9. [DOI] [PubMed] [Google Scholar]
  29. Gaasch W. H., Zile M. R., Hoshino P. K., Apstein C. S., Blaustein A. S. Stress-shortening relations and myocardial blood flow in compensated and failing canine hearts with pressure-overload hypertrophy. Circulation. 1989 Apr;79(4):872–883. doi: 10.1161/01.cir.79.4.872. [DOI] [PubMed] [Google Scholar]
  30. Gasic S., Dudczak R., Korn A., Kleinbloesem C. ACE inhibition with cilazapril improves myocardial perfusion to the ischemic regions during exercise: a pilot study. J Cardiovasc Pharmacol. 1990 Feb;15(2):227–232. doi: 10.1097/00005344-199002000-00008. [DOI] [PubMed] [Google Scholar]
  31. Gavras H., Faxon D. P., Berkoben J., Brunner H. R., Ryan T. J. Angiotensin converting enzyme inhibition in patients with congestive heart failure. Circulation. 1978 Nov;58(5):770–776. doi: 10.1161/01.cir.58.5.770. [DOI] [PubMed] [Google Scholar]
  32. Gerlings E. D., Gilmore J. P. Evidence for myocardial conversion of angiotensin I. Basic Res Cardiol. 1974 May-Jun;69(3):222–227. doi: 10.1007/BF01906203. [DOI] [PubMed] [Google Scholar]
  33. Gewirtz H., Most A. S., Williams D. O. The effect of generalized alpha-receptor stimulation on regional myocardial blood flow distal to a severe coronary artery stenosis. Circulation. 1982 Jun;65(7):1329–1336. doi: 10.1161/01.cir.65.7.1329. [DOI] [PubMed] [Google Scholar]
  34. Gibbons G. H., Dzau V. J. Angiotensin converting enzyme inhibition and vascular hypertrophy in hypertension. Cardiovasc Drugs Ther. 1990 Feb;4(1):237–242. doi: 10.1007/BF01857638. [DOI] [PubMed] [Google Scholar]
  35. Gorman M. W., Sparks H. V., Jr Progressive coronary vasoconstriction during relative ischemia in canine myocardium. Circ Res. 1982 Oct;51(4):411–420. doi: 10.1161/01.res.51.4.411. [DOI] [PubMed] [Google Scholar]
  36. Guyton R. A., McClenathan J. H., Michaelis L. L. Evolution of regional ischemia distal to a proximal coronary stenosis: self-propagation of ischemia. Am J Cardiol. 1977 Sep;40(3):381–392. doi: 10.1016/0002-9149(77)90160-6. [DOI] [PubMed] [Google Scholar]
  37. Han H., Tian R., Neubauer S., Gaudron P., Hu K., Ertl G. Effects of LTD4 and its specific antagonist L-660,711 in isolated rat hearts with chronic myocardial infarction. Am J Physiol. 1994 May;266(5 Pt 2):H2068–H2073. doi: 10.1152/ajpheart.1994.266.5.H2068. [DOI] [PubMed] [Google Scholar]
  38. Heusch G., Deussen A. The effects of cardiac sympathetic nerve stimulation on perfusion of stenotic coronary arteries in the dog. Circ Res. 1983 Jul;53(1):8–15. doi: 10.1161/01.res.53.1.8. [DOI] [PubMed] [Google Scholar]
  39. Hittinger L., Shannon R. P., Bishop S. P., Gelpi R. J., Vatner S. F. Subendomyocardial exhaustion of blood flow reserve and increased fibrosis in conscious dogs with heart failure. Circ Res. 1989 Oct;65(4):971–980. doi: 10.1161/01.res.65.4.971. [DOI] [PubMed] [Google Scholar]
  40. Holtz J., Busse R., Sommer O., Bassenge E. Dilation of epicardial arteries in conscious dogs induced by angiotensin-converting enzyme inhibition with enalaprilat. J Cardiovasc Pharmacol. 1987 Mar;9(3):348–355. doi: 10.1097/00005344-198703000-00011. [DOI] [PubMed] [Google Scholar]
  41. Horn M., Neubauer S., Frantz S., Hugel S., Hu K., Gaudron P., Schnackerz K., Ertl G. Preservation of left ventricular mechanical function and energy metabolism in rats after myocardial infarction by the angiotensin-converting enzyme inhibitor quinapril. J Cardiovasc Pharmacol. 1996 Feb;27(2):201–210. doi: 10.1097/00005344-199602000-00005. [DOI] [PubMed] [Google Scholar]
  42. Ikram H., Low C. J., Shirlaw T., Webb C. M., Richards A. M., Crozier I. G. Antianginal, hemodynamic and coronary vascular effects of captopril in stable angina pectoris. Am J Cardiol. 1990 Jul 15;66(2):164–167. doi: 10.1016/0002-9149(90)90581-k. [DOI] [PubMed] [Google Scholar]
  43. Isoyama S., Ito N., Satoh K., Takishima T. Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy. Hypertension. 1992 Oct;20(4):491–500. doi: 10.1161/01.hyp.20.4.491. [DOI] [PubMed] [Google Scholar]
  44. Janiak P., Libert O., Vilaine J. P. Role of the renin-angiotensin system in neointima formation after injury in rabbits. Hypertension. 1994 Dec;24(6):671–678. doi: 10.1161/01.hyp.24.6.671. [DOI] [PubMed] [Google Scholar]
  45. Karam R., Healy B. P., Wicker P. Coronary reserve is depressed in postmyocardial infarction reactive cardiac hypertrophy. Circulation. 1990 Jan;81(1):238–246. doi: 10.1161/01.cir.81.1.238. [DOI] [PubMed] [Google Scholar]
  46. Laser A., Neubauer S., Tian R., Hu K., Gaudron P., Ingwall J. S., Ertl G. Long-term beta-blocker treatment prevents chronic creatine kinase and lactate dehydrogenase system changes in rat hearts after myocardial infarction. J Am Coll Cardiol. 1996 Feb;27(2):487–493. doi: 10.1016/0735-1097(95)00458-0. [DOI] [PubMed] [Google Scholar]
  47. Laxson D. D., Dai X. Z., Homans D. C., Bache R. J. Coronary vasodilator reserve in ischemic myocardium of the exercising dog. Circulation. 1992 Jan;85(1):313–322. doi: 10.1161/01.cir.85.1.313. [DOI] [PubMed] [Google Scholar]
  48. Liang C. S., Gavras H. Renin-angiotensin system inhibition in conscious dogs during acute hypoxemia. Effects on systemic hemodynamics, regional blood flows, and tissue metabolism. J Clin Invest. 1978 Nov;62(5):961–970. doi: 10.1172/JCI109225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Linz W., Schölkens B. A., Han Y. F. Beneficial effects of the converting enzyme inhibitor, ramipril, in ischemic rat hearts. J Cardiovasc Pharmacol. 1986;8 (Suppl 10):S91–S99. doi: 10.1097/00005344-198600101-00017. [DOI] [PubMed] [Google Scholar]
  50. Linz W., Schölkens B. A. Influence of local converting enzyme inhibition on angiotensin and bradykinin effects in ischemic rat hearts. J Cardiovasc Pharmacol. 1987;10 (Suppl 7):S75–S82. doi: 10.1097/00005344-198706107-00012. [DOI] [PubMed] [Google Scholar]
  51. Liu Y. H., Yang X. P., Sharov V. G., Sigmon D. H., Sabbath H. N., Carretero O. A. Paracrine systems in the cardioprotective effect of angiotensin-converting enzyme inhibitors on myocardial ischemia/reperfusion injury in rats. Hypertension. 1996 Jan;27(1):7–13. doi: 10.1161/01.hyp.27.1.7. [DOI] [PubMed] [Google Scholar]
  52. Magrini F., Reggiani P., Roberts N., Meazza R., Ciulla M., Zanchetti A. Effects of angiotensin and angiotensin blockade on coronary circulation and coronary reserve. Am J Med. 1988 Mar 11;84(3A):55–60. doi: 10.1016/0002-9343(88)90205-7. [DOI] [PubMed] [Google Scholar]
  53. Magrini F., Shimizu M., Roberts N., Fouad F. M., Tarazi R. C., Zanchetti A. Converting-enzyme inhibition and coronary blood flow. Circulation. 1987 Jan;75(1 Pt 2):I168–I174. [PubMed] [Google Scholar]
  54. Malik A. B., Geha A. S. Cardiac function, coronary flow and MVO2 in hypertrophy induced by pressure and volume overloading. Cardiovasc Res. 1977 Jul;11(4):310–316. doi: 10.1093/cvr/11.4.310. [DOI] [PubMed] [Google Scholar]
  55. McAlpine H. M., Morton J. J., Leckie B., Dargie H. J. Haemodynamic effects of captopril in acute left ventricular failure complicating myocardial infarction. J Cardiovasc Pharmacol. 1987;9 (Suppl 2):S25–S30. doi: 10.1097/00005344-198700002-00007. [DOI] [PubMed] [Google Scholar]
  56. Michorowski B., Ceremuzyński L. The renin-angiotensin--aldosterone system and the clinical course of acute myocardial infarction. Eur Heart J. 1983 Apr;4(4):259–264. doi: 10.1093/oxfordjournals.eurheartj.a061457. [DOI] [PubMed] [Google Scholar]
  57. Mudge G. H., Jr, Grossman W., Mills R. M., Jr, Lesch M., Braunwald E. Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med. 1976 Dec 9;295(24):1333–1337. doi: 10.1056/NEJM197612092952401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Mueller T. M., Marcus M. L., Kerber R. E., Young J. A., Barnes R. W., Abboud F. M. Effect of renal hypertension and left ventricular hypertrophy on the coronary circulation in dogs. Circ Res. 1978 Apr;42(4):543–549. doi: 10.1161/01.res.42.4.543. [DOI] [PubMed] [Google Scholar]
  59. Nelissen-Vrancken H. J., Debets J. J., Snoeckx L. H., Daemen M. J., Smits J. F. Time-related normalization of maximal coronary flow in isolated perfused hearts of rats with myocardial infarction. Circulation. 1996 Jan 15;93(2):349–355. doi: 10.1161/01.cir.93.2.349. [DOI] [PubMed] [Google Scholar]
  60. Neubauer S., Horn M., Naumann A., Tian R., Hu K., Laser M., Friedrich J., Gaudron P., Schnackerz K., Ingwall J. S. Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest. 1995 Mar;95(3):1092–1100. doi: 10.1172/JCI117756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Nicoletti A., Heudes D., Hinglais N., Appay M. D., Philippe M., Sassy-Prigent C., Bariety J., Michel J. B. Left ventricular fibrosis in renovascular hypertensive rats. Effect of losartan and spironolactone. Hypertension. 1995 Jul;26(1):101–111. doi: 10.1161/01.hyp.26.1.101. [DOI] [PubMed] [Google Scholar]
  62. O'Gorman D. J., Thomas P., Turner M. A., Sheridan D. J. Investigation of impaired coronary vasodilator reserve in the guinea pig heart with pressure induced hypertrophy. Eur Heart J. 1992 May;13(5):697–703. doi: 10.1093/oxfordjournals.eurheartj.a060237. [DOI] [PubMed] [Google Scholar]
  63. Olivetti G., Capasso J. M., Meggs L. G., Sonnenblick E. H., Anversa P. Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ Res. 1991 Mar;68(3):856–869. doi: 10.1161/01.res.68.3.856. [DOI] [PubMed] [Google Scholar]
  64. Osterrieder W., Müller R. K., Powell J. S., Clozel J. P., Hefti F., Baumgartner H. R. Role of angiotensin II in injury-induced neointima formation in rats. Hypertension. 1991 Oct;18(4 Suppl):II60–II64. doi: 10.1161/01.hyp.18.4_suppl.ii60. [DOI] [PubMed] [Google Scholar]
  65. Parodi O., Sambuceti G., Roghi A., Testa R., Inglese E., Pirelli S., Spinelli F., Campolo L., L'Abbate A. Residual coronary reserve despite decreased resting blood flow in patients with critical coronary lesions. A study by technetium-99m human albumin microsphere myocardial scintigraphy. Circulation. 1993 Feb;87(2):330–344. doi: 10.1161/01.cir.87.2.330. [DOI] [PubMed] [Google Scholar]
  66. Perondi R., Saino A., Tio R. A., Pomidossi G., Gregorini L., Alessio P., Morganti A., Zanchetti A., Mancia G. ACE inhibition attenuates sympathetic coronary vasoconstriction in patients with coronary artery disease. Circulation. 1992 Jun;85(6):2004–2013. doi: 10.1161/01.cir.85.6.2004. [DOI] [PubMed] [Google Scholar]
  67. Piana R. N., Wang S. Y., Friedman M., Sellke F. W. Angiotensin-converting enzyme inhibition preserves endothelium-dependent coronary microvascular responses during short-term ischemia-reperfusion. Circulation. 1996 Feb 1;93(3):544–551. doi: 10.1161/01.cir.93.3.544. [DOI] [PubMed] [Google Scholar]
  68. Pinto J. E., Viglione P., Saavedra J. M. Autoradiographic localization and quantification of rat heart angiotensin converting enzyme. Am J Hypertens. 1991 Apr;4(4 Pt 1):321–326. doi: 10.1093/ajh/4.4.321. [DOI] [PubMed] [Google Scholar]
  69. Powell J. S., Müller R. K., Rouge M., Kuhn H., Hefti F., Baumgartner H. R. The proliferative response to vascular injury is suppressed by angiotensin-converting enzyme inhibition. J Cardiovasc Pharmacol. 1990;16 (Suppl 4):S42–S49. doi: 10.1097/00005344-199016004-00010. [DOI] [PubMed] [Google Scholar]
  70. Pratt R. E., Dzau V. J. Pharmacological strategies to prevent restenosis: lessons learned from blockade of the renin-angiotensin system. Circulation. 1996 Mar 1;93(5):848–852. doi: 10.1161/01.cir.93.5.848. [DOI] [PubMed] [Google Scholar]
  71. Pupita G., Maseri A., Kaski J. C., Galassi A. R., Gavrielides S., Davies G., Crea F. Myocardial ischemia caused by distal coronary-artery constriction in stable angina pectoris. N Engl J Med. 1990 Aug 23;323(8):514–520. doi: 10.1056/NEJM199008233230804. [DOI] [PubMed] [Google Scholar]
  72. Rouleau J. L., Chatterjee K., Benge W., Parmley W. W., Hiramatsu B. Alterations in left ventricular function and coronary hemodynamics with captopril, hydralazine and prazosin in chronic ischemic heart failure: a comparative study. Circulation. 1982 Apr;65(4):671–678. doi: 10.1161/01.cir.65.4.671. [DOI] [PubMed] [Google Scholar]
  73. Rump A. F., Rösen R., Korth A., Klaus W. Deleterious effect of exogenous angiotensin-I on the extent of regional ischaemia and its inhibition by captopril. Eur Heart J. 1993 Jan;14(1):106–112. doi: 10.1093/eurheartj/14.1.106. [DOI] [PubMed] [Google Scholar]
  74. Schorb W., Booz G. W., Dostal D. E., Conrad K. M., Chang K. C., Baker K. M. Angiotensin II is mitogenic in neonatal rat cardiac fibroblasts. Circ Res. 1993 Jun;72(6):1245–1254. doi: 10.1161/01.res.72.6.1245. [DOI] [PubMed] [Google Scholar]
  75. Schultheiss H. P., Ullrich G., Schindler M., Schulze K., Strauer B. E. The effect of ACE inhibition on myocardial energy metabolism. Eur Heart J. 1990 Apr;11 (Suppl B):116–122. doi: 10.1093/eurheartj/11.suppl_b.116. [DOI] [PubMed] [Google Scholar]
  76. Seitelberger R., Guth B. D., Heusch G., Lee J. D., Katayama K., Ross J., Jr Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exercise. Circ Res. 1988 Mar;62(3):436–442. doi: 10.1161/01.res.62.3.436. [DOI] [PubMed] [Google Scholar]
  77. Skidgel R. A., Engelbrecht S., Johnson A. R., Erdös E. G. Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides. 1984 Jul-Aug;5(4):769–776. doi: 10.1016/0196-9781(84)90020-2. [DOI] [PubMed] [Google Scholar]
  78. Strauer B. E. Myocardial oxygen consumption in chronic heart disease: role of wall stress, hypertrophy and coronary reserve. Am J Cardiol. 1979 Oct;44(4):730–740. doi: 10.1016/0002-9149(79)90295-9. [DOI] [PubMed] [Google Scholar]
  79. Sudhir K., MacGregor J. S., Gupta M., Barbant S. D., Redberg R., Yock P. G., Chatterjee K. Effect of selective angiotensin II receptor antagonism and angiotensin converting enzyme inhibition on the coronary vasculature in vivo. Intravascular two-dimensional and Doppler ultrasound studies. Circulation. 1993 Mar;87(3):931–938. doi: 10.1161/01.cir.87.3.931. [DOI] [PubMed] [Google Scholar]
  80. Unverferth D. V., Magorien R. D., Lewis R. P., Leier C. V. The role of subendocardial ischemia in perpetuating myocardial failure in patients with nonischemic congestive cardiomyopathy. Am Heart J. 1983 Jan;105(1):176–179. doi: 10.1016/0002-8703(83)90305-8. [DOI] [PubMed] [Google Scholar]
  81. Uren N. G., Crake T., Lefroy D. C., de Silva R., Davies G. J., Maseri A. Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction. N Engl J Med. 1994 Jul 28;331(4):222–227. doi: 10.1056/NEJM199407283310402. [DOI] [PubMed] [Google Scholar]
  82. Villarreal F. J., Kim N. N., Ungab G. D., Printz M. P., Dillmann W. H. Identification of functional angiotensin II receptors on rat cardiac fibroblasts. Circulation. 1993 Dec;88(6):2849–2861. doi: 10.1161/01.cir.88.6.2849. [DOI] [PubMed] [Google Scholar]
  83. Vinten-Johansen J., Weiss H. R. Oxygen consumption in subepicardial and subendocardial regions of the canine left ventricle. The effect of experimental acute valvular aortic stenosis. Circ Res. 1980 Jan;46(1):139–145. doi: 10.1161/01.res.46.1.139. [DOI] [PubMed] [Google Scholar]
  84. Vitullo J. C., Penn M. S., Rakusan K., Wicker P. Effects of hypertension and aging on coronary arteriolar density. Hypertension. 1993 Apr;21(4):406–414. doi: 10.1161/01.hyp.21.4.406. [DOI] [PubMed] [Google Scholar]
  85. Weber K. T., Sun Y., Katwa L. C., Cleutjens J. P. Connective tissue: a metabolic entity? . J Mol Cell Cardiol. 1995 Jan;27(1):107–120. doi: 10.1016/s0022-2828(08)80011-9. [DOI] [PubMed] [Google Scholar]
  86. Weiss M. B., Ellis K., Sciacca R. R., Johnson L. L., Schmidt D. H., Cannon P. J. Myocardial blood flow in congestive and hypertrophic cardiomyopathy: relationship to peak wall stress and mean velocity of circumferential fiber shortening. Circulation. 1976 Sep;54(3):484–494. doi: 10.1161/01.cir.54.3.484. [DOI] [PubMed] [Google Scholar]
  87. Wicker P., Abdul-Samad M., Rakusan K., Tarazi R. C., Healy B. Effects of chronic exercise on the coronary circulation in conscious rats with renovascular hypertension. Hypertension. 1987 Jul;10(1):74–81. doi: 10.1161/01.hyp.10.1.74. [DOI] [PubMed] [Google Scholar]
  88. Xiang J. Z., Schölkens B. A., Ganten D., Unger T. Effects of sympathetic nerve stimulation are attenuated by the converting enzyme inhibitor Hoe 498 in isolated rabbit hearts. Clin Exp Hypertens A. 1984;6(10-11):1853–1857. doi: 10.3109/10641968409046091. [DOI] [PubMed] [Google Scholar]
  89. Yamada H., Fabris B., Allen A. M., Jackson B., Johnston C. I., Mendelsohn A. O. Localization of angiotensin converting enzyme in rat heart. Circ Res. 1991 Jan;68(1):141–149. doi: 10.1161/01.res.68.1.141. [DOI] [PubMed] [Google Scholar]
  90. Zimmerman B. G., Sybertz E. J., Wong P. C. Interaction between sympathetic and renin-angiotensin system. J Hypertens. 1984 Dec;2(6):581–587. doi: 10.1097/00004872-198412000-00002. [DOI] [PubMed] [Google Scholar]

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