Figure 6.

Schematic of DBS effects on STN-cortical networks. Mesial premotor areas, including the SMA are preferentially coupled to the STN at rest at high (red) rather than at low (green) beta frequencies. This pattern is not observed for lateral motor areas, including parts of M1, where coupling to the STN is more evenly distributed across beta frequencies. STN DBS acts to suppress driving of the STN by mesial premotor regions in the low and high beta sub-bands. Crucially these effects of DBS are limited to the STN-mesial premotor network and are not observed in the patterns of DBS reactivity of the STN-lateral motor network (see ‘Discussion’ section).