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. 1996 Oct;76(4):305–307. doi: 10.1136/hrt.76.4.305

Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease.

J J Sung 1, J E Sanderson 1
PMCID: PMC484538  PMID: 8983673

Abstract

Hyperhomocysteinaemia and Helicobacter pylori infection have recently been implicated in the pathogenesis of coronary artery disease. These two risk factors, though they seem unrelated, could be linked by a deficiency of vitamins and folate caused by chronic gastritis in H pylori infection. This nutritional defect could lead to failure of methylation by 5-methyl-tetrahydrofolic acid and thus exacerbate the accumulation of homocysteine in susceptible patients. Homocysteine is toxic to endothelial cells and results in coronary artery disease.

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Selected References

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