Table 1.
Characteristics of AluYa5/Yb8 elements located within 1-kb of the nearest transcription start site (TSS) and their associated gene. Loci were subdivided into three broad groups: Low (0-50%), Medium (50-75%) and High methylation (75-100%). Negative sign (-) indicates that the gene is upstream of the transcription start site (TSS).
| Gene | Alu Subfamily | Methylation Level (%) | Group | Distance to nearest TSS (bp) | H3K27ac shore | Hypo-methylated Tissue(s) |
|---|---|---|---|---|---|---|
| OR10Q1 | Ya5 | 82 | High | -160 | — | Sperm |
| OSBPL10 | Ya5 | 17 | Low | -160 | Yes | Various |
| TMSB4Y | Ya5 | 24 | Low | -200 | — | Various |
| †UBE2T | †Ya5 | 8 | Low | 529 | Yes | Various |
| †CEBPG | †Ya5 | 83 | High | -578 | Yes | Various |
| HIGD1B | Yb8 | 66 | Medium | -603 | — | — |
| †DHODH | †Yb8 | 21 | Low | 634 | Yes | Various |
| RABEPK | Yb8 | 44 | Low | -660 | Yes | Various |
| UGGT2 | Ya5 | 17 | Low | -698 | Yes | Various |
| HENMT1 | Ya5 | 66 | Medium | 729 | — | Various |
| INTS5 | Yb8 | 97 | High | -779 | Yes | Sperm |
| HTR3E | Yb8 | 83 | High | -783 | Yes | Sperm |
| †MAP3K7 (TAK1) | †Yb8 | 20 | Low | 798 | Yes | Various |
| AASDH | Yb8 | 66 | Medium | 830 | Yes | Various |
| ADAD1 | Ya5 | 88 | High | -854 | — | Sperm |
| IDNK | Yb8 | 84 | High | -931 | — | Sperm |
| †EDAR | †Yb8 | 61 | Medium | -936 | — | — |
| EIF2B1 | Ya5 | 89 | High | 952 | — | Sperm |
† Loci further characterized in this study