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. 2016 Jan 19;11(1):24–35. doi: 10.1080/15592294.2015.1127479

Figure 1.

Figure 1.

Allelic-skewing is less prevalent and less variable across cortical regions compared to cerebellum and whole blood. (A) The average proportion of informative amplicons showing an ASM score ≥ 0.10 for the 6 cortical regions profiled as well as averaged across the cortical areas (Ctx) is consistently lower (ASM score range = 0.34–0.61%) than in cerebellum (Cer) (ASM prevalence = 1.14%) or blood (ASM prevalence = 0.84%). Standard errors are shown for tissues for which samples were available from all 3 individuals. (B) – (E) Correlations of ASM scores are shown with each point representing one probe in one individual. Probes classified as allelically-skewed at an ASM score ≥ 0.10 in only one of the 2 compared tissues are highlighted in red. A higher degree of between-tissue variability is observed between cerebellum, cortex, and whole blood than between different cortical regions (shown as an example is BA8 vs. BA10). This difference becomes even more pronounced when restricting the set of probes to those that show allelic-skewing at an ASM score ≥ 0.10 in at least one of the 2 compared tissues (see subset correlation r’).