Skip to main content
Heart logoLink to Heart
editorial
. 1997 Jan;77(1):5–6. doi: 10.1136/hrt.77.1.5

Is long QT syndrome entering the era of molecular diagnosis?

S G Priori
PMCID: PMC484623  PMID: 9038683

Full text

PDF
5

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett P. B., Yazawa K., Makita N., George A. L., Jr Molecular mechanism for an inherited cardiac arrhythmia. Nature. 1995 Aug 24;376(6542):683–685. doi: 10.1038/376683a0. [DOI] [PubMed] [Google Scholar]
  2. Curran M. E., Splawski I., Timothy K. W., Vincent G. M., Green E. D., Keating M. T. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 1995 Mar 10;80(5):795–803. doi: 10.1016/0092-8674(95)90358-5. [DOI] [PubMed] [Google Scholar]
  3. Dumaine R., Wang Q., Keating M. T., Hartmann H. A., Schwartz P. J., Brown A. M., Kirsch G. E. Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res. 1996 May;78(5):916–924. doi: 10.1161/01.res.78.5.916. [DOI] [PubMed] [Google Scholar]
  4. Jiang C., Atkinson D., Towbin J. A., Splawski I., Lehmann M. H., Li H., Timothy K., Taggart R. T., Schwartz P. J., Vincent G. M. Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. Nat Genet. 1994 Oct;8(2):141–147. doi: 10.1038/ng1094-141. [DOI] [PubMed] [Google Scholar]
  5. Keating M., Atkinson D., Dunn C., Timothy K., Vincent G. M., Leppert M. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science. 1991 May 3;252(5006):704–706. doi: 10.1126/science.1673802. [DOI] [PubMed] [Google Scholar]
  6. Priori S. G., Napolitano C., Cantù F., Brown A. M., Schwartz P. J. Differential response to Na+ channel blockade, beta-adrenergic stimulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circ Res. 1996 Jun;78(6):1009–1015. doi: 10.1161/01.res.78.6.1009. [DOI] [PubMed] [Google Scholar]
  7. Sanguinetti M. C., Curran M. E., Spector P. S., Keating M. T. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2208–2212. doi: 10.1073/pnas.93.5.2208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Schott J. J., Charpentier F., Peltier S., Foley P., Drouin E., Bouhour J. B., Donnelly P., Vergnaud G., Bachner L., Moisan J. P. Mapping of a gene for long QT syndrome to chromosome 4q25-27. Am J Hum Genet. 1995 Nov;57(5):1114–1122. [PMC free article] [PubMed] [Google Scholar]
  9. Schwartz P. J. Idiopathic long QT syndrome: progress and questions. Am Heart J. 1985 Feb;109(2):399–411. doi: 10.1016/0002-8703(85)90626-x. [DOI] [PubMed] [Google Scholar]
  10. Schwartz P. J., Priori S. G., Locati E. H., Napolitano C., Cantù F., Towbin J. A., Keating M. T., Hammoude H., Brown A. M., Chen L. S. Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 1995 Dec 15;92(12):3381–3386. doi: 10.1161/01.cir.92.12.3381. [DOI] [PubMed] [Google Scholar]
  11. Towbin J. A., Li H., Taggart R. T., Lehmann M. H., Schwartz P. J., Satler C. A., Ayyagari R., Robinson J. L., Moss A., Hejtmancik J. F. Evidence of genetic heterogeneity in Romano-Ward long QT syndrome. Analysis of 23 families. Circulation. 1994 Dec;90(6):2635–2644. doi: 10.1161/01.cir.90.6.2635. [DOI] [PubMed] [Google Scholar]
  12. Wang Q., Curran M. E., Splawski I., Burn T. C., Millholland J. M., VanRaay T. J., Shen J., Timothy K. W., Vincent G. M., de Jager T. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet. 1996 Jan;12(1):17–23. doi: 10.1038/ng0196-17. [DOI] [PubMed] [Google Scholar]
  13. Wang Q., Li Z., Shen J., Keating M. T. Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics. 1996 May 15;34(1):9–16. doi: 10.1006/geno.1996.0236. [DOI] [PubMed] [Google Scholar]
  14. Wang Q., Shen J., Li Z., Timothy K., Vincent G. M., Priori S. G., Schwartz P. J., Keating M. T. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum Mol Genet. 1995 Sep;4(9):1603–1607. doi: 10.1093/hmg/4.9.1603. [DOI] [PubMed] [Google Scholar]
  15. Wang Q., Shen J., Splawski I., Atkinson D., Li Z., Robinson J. L., Moss A. J., Towbin J. A., Keating M. T. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 1995 Mar 10;80(5):805–811. doi: 10.1016/0092-8674(95)90359-3. [DOI] [PubMed] [Google Scholar]
  16. Watkins H., Rosenzweig A., Hwang D. S., Levi T., McKenna W., Seidman C. E., Seidman J. G. Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy. N Engl J Med. 1992 Apr 23;326(17):1108–1114. doi: 10.1056/NEJM199204233261703. [DOI] [PubMed] [Google Scholar]

Articles from Heart are provided here courtesy of BMJ Publishing Group

RESOURCES