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. 1997 Sep;78(3):273–277. doi: 10.1136/hrt.78.3.273

Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease.

M A Mendall 1, P Patel 1, M Asante 1, L Ballam 1, J Morris 1, D P Strachan 1, A J Camm 1, T C Northfield 1
PMCID: PMC484930  PMID: 9391290

Abstract

OBJECTIVE: To determine whether serum concentrations of the cytokines tumour necrosis factor alpha (TNF alpha) and interleukin 6 (IL-6), which regulate C reactive protein, are associated with cardiovascular risk factors and prevalent coronary heart disease. DESIGN: A population based cross sectional study. SUBJECTS AND METHODS: 198 men aged 50 to 69 years were part of a random population sample drawn from south London. Serum cytokine and C reactive protein concentrations were determined by enzyme linked immunosorbent assay. The presence of coronary heart disease was determined by Rose angina questionnaire and Minnesota coded electrocardiogram. RESULTS: Serum TNF alpha concentrations were positively related to body mass index and Helicobacter pylori infection, but inversely related to alcohol consumption. IL-6 concentrations were positively associated with smoking, symptoms of chronic bronchitis, age, and father having a manual occupation. TNF alpha was associated with increased IL-6 and triglycerides, and reduced high density lipoprotein cholesterol. IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides. ECG abnormalities were independently associated with increases in IL-6 and TNF alpha, each by approximately 50% (P < 0.05 for TNF alpha, P < 0.1 for IL-6). The corresponding increases in men with an abnormal ECG or symptomatic coronary heart disease were 28% for TNF alpha and 36% for IL-6 (P = 0.14 for TNF alpha and P < 0.05 for IL-6). CONCLUSIONS: This study confirms that many of the phenomena with which C reactive protein is associated, are also associated with serum levels of cytokine, which may be the mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alvarez C., Ramos A. Lipids, lipoproteins, and apoproteins in serum during infection. Clin Chem. 1986 Jan;32(1 Pt 1):142–145. [PubMed] [Google Scholar]
  2. Baumann H., Gauldie J. The acute phase response. Immunol Today. 1994 Feb;15(2):74–80. doi: 10.1016/0167-5699(94)90137-6. [DOI] [PubMed] [Google Scholar]
  3. Brunner E., Davey Smith G., Marmot M., Canner R., Beksinska M., O'Brien J. Childhood social circumstances and psychosocial and behavioural factors as determinants of plasma fibrinogen. Lancet. 1996 Apr 13;347(9007):1008–1013. doi: 10.1016/s0140-6736(96)90147-6. [DOI] [PubMed] [Google Scholar]
  4. Cabana V. G., Siegel J. N., Sabesin S. M. Effects of the acute phase response on the concentration and density distribution of plasma lipids and apolipoproteins. J Lipid Res. 1989 Jan;30(1):39–49. [PubMed] [Google Scholar]
  5. Chirmule N., Oyaizu N., Kalyanaraman V. S., Pahwa S. Misinterpretation of results of cytokine bioassays. J Immunol Methods. 1991 Mar 1;137(1):141–144. doi: 10.1016/0022-1759(91)90403-3. [DOI] [PubMed] [Google Scholar]
  6. Facchini F. S., Hollenbeck C. B., Jeppesen J., Chen Y. D., Reaven G. M. Insulin resistance and cigarette smoking. Lancet. 1992 May 9;339(8802):1128–1130. doi: 10.1016/0140-6736(92)90730-q. [DOI] [PubMed] [Google Scholar]
  7. Fahie-Wilson M., Mills R., Wilson K. HDL cholesterol and the acute phase reaction following myocardial infarction and acute pancreatitis. Clin Chim Acta. 1987 Aug 14;167(2):197–209. doi: 10.1016/0009-8981(87)90372-x. [DOI] [PubMed] [Google Scholar]
  8. Feingold K. R., Grunfeld C. Role of cytokines in inducing hyperlipidemia. Diabetes. 1992 Oct;41 (Suppl 2):97–101. doi: 10.2337/diab.41.2.s97. [DOI] [PubMed] [Google Scholar]
  9. Folsom A. R., Qamhieh H. T., Flack J. M., Hilner J. E., Liu K., Howard B. V., Tracy R. P. Plasma fibrinogen: levels and correlates in young adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol. 1993 Dec 15;138(12):1023–1036. doi: 10.1093/oxfordjournals.aje.a116821. [DOI] [PubMed] [Google Scholar]
  10. Greer I. A., Lyall F., Perera T., Boswell F., Macara L. M. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol. 1994 Dec;84(6):937–940. [PubMed] [Google Scholar]
  11. Grunfeld C., Adi S., Soued M., Moser A., Fiers W., Feingold K. R. Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6. Cancer Res. 1990 Jul 15;50(14):4233–4238. [PubMed] [Google Scholar]
  12. Heldenberg D., Rubinstein A., Levtov O., Berns L., Werbin B., Tamir I. Serum lipids and lipoprotein concentrations during the acute phase of myocardial infarction. Atherosclerosis. 1980 Apr;35(4):433–437. doi: 10.1016/0021-9150(80)90184-7. [DOI] [PubMed] [Google Scholar]
  13. Hotamisligil G. S., Arner P., Caro J. F., Atkinson R. L., Spiegelman B. M. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995 May;95(5):2409–2415. doi: 10.1172/JCI117936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hotamisligil G. S., Shargill N. S., Spiegelman B. M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993 Jan 1;259(5091):87–91. doi: 10.1126/science.7678183. [DOI] [PubMed] [Google Scholar]
  15. Juhan-Vague I., Thompson S. G., Jespersen J. Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group. Arterioscler Thromb. 1993 Dec;13(12):1865–1873. doi: 10.1161/01.atv.13.12.1865. [DOI] [PubMed] [Google Scholar]
  16. Kiechl S., Willeit J., Poewe W., Egger G., Oberhollenzer F., Muggeo M., Bonora E. Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study) BMJ. 1996 Oct 26;313(7064):1040–1044. doi: 10.1136/bmj.313.7064.1040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maseri A., Biasucci L. M., Liuzzo G. Inflammation in ischaemic heart disease. BMJ. 1996 Apr 27;312(7038):1049–1050. doi: 10.1136/bmj.312.7038.1049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mendall M. A., Patel P., Ballam L., Strachan D., Northfield T. C. C reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study. BMJ. 1996 Apr 27;312(7038):1061–1065. doi: 10.1136/bmj.312.7038.1061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Nelson S., Bagby G. J., Bainton B. G., Summer W. R. The effects of acute and chronic alcoholism on tumor necrosis factor and the inflammatory response. J Infect Dis. 1989 Sep;160(3):422–429. doi: 10.1093/infdis/160.3.422. [DOI] [PubMed] [Google Scholar]
  20. Patel P., Mendall M. A., Carrington D., Strachan D. P., Leatham E., Molineaux N., Levy J., Blakeston C., Seymour C. A., Camm A. J. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ. 1995 Sep 16;311(7007):711–714. doi: 10.1136/bmj.311.7007.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. ROSE G. A. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ. 1962;27:645–658. [PMC free article] [PubMed] [Google Scholar]
  22. Rose G., Baxter P. J., Reid D. D., McCartney P. Prevalence and prognosis of electrocardiographic findings in middle-aged men. Br Heart J. 1978 Jun;40(6):636–643. doi: 10.1136/hrt.40.6.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993 Apr 29;362(6423):801–809. doi: 10.1038/362801a0. [DOI] [PubMed] [Google Scholar]

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