Abstract
OBJECTIVE: To determine the effects of ibopamine 100 mg three times daily compared with captopril 25 mg three times daily on exercise capacity in patients with chronic heart failure. DESIGN: A randomised, double blind, parallel group comparison of the addition of ibopamine versus captopril during a period of 24 weeks. SETTING: 26 outpatient cardiology clinics in seven European countries. PATIENTS: 266 patients, with mild to moderate chronic heart failure (New York Heart Association (NYHA) functional class II, 81% and III, 19%) and evidence of an enlarged left ventricle. Patients received concomitant treatment with diuretics and/or digitalis. MAIN OUTCOME MEASURE: Exercise duration after 24 weeks of treatment, compared with baseline. RESULTS: Mean (SD) ejection fraction was 29 (8)% and the baseline exercise duration in the captopril and ibopamine groups 665 (160) and 675 (174) seconds, respectively. At the end of the study, exercise duration had improved in both groups, by 29 seconds in the ibopamine group (P < 0.01), and by 24 seconds in the captopril group (P < 0.05). There was no difference between groups (P = 0.69, 95% confidence interval -22 to 33). NYHA class, signs and symptoms score, and dyspnoea and fatigue index improved equally in both groups. The total number of adverse events was the same in both treatment groups, but gastrointestinal complaints occurred more often in the ibopamine group. The number of patients with premature withdrawals was no different. CONCLUSIONS: No difference was detected between the effect of captopril and ibopamine on exercise time in patients with mild to moderate heart failure during a treatment period of 24 weeks.
Full text
PDF





Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barabino A., Galbariggi G., Pizzorni C., Lotti G. Comparative effects of long-term therapy with captopril and ibopamine in chronic congestive heart failure in old patients. Cardiology. 1991;78(3):243–256. doi: 10.1159/000174791. [DOI] [PubMed] [Google Scholar]
- Brown E. J., Jr, Chew P. H., MacLean A., Gelperin K., Ilgenfritz J. P., Blumenthal M. Effects of fosinopril on exercise tolerance and clinical deterioration in patients with chronic congestive heart failure not taking digitalis. Fosinopril Heart Failure Study Group. Am J Cardiol. 1995 Mar 15;75(8):596–600. doi: 10.1016/s0002-9149(99)80624-9. [DOI] [PubMed] [Google Scholar]
- Cavalli A., Riva E., Schleman M., Abbondati G., Fuccella L. M. Ibopamine as a substitute for digitalis in patients with congestive heart failure on chronic digoxin therapy. Smith Kline and French Ibopamine Group. Int J Cardiol. 1989 Mar;22(3):381–387. doi: 10.1016/0167-5273(89)90280-5. [DOI] [PubMed] [Google Scholar]
- Cohn J. N. The prevention of heart failure--a new agenda. N Engl J Med. 1992 Sep 3;327(10):725–727. doi: 10.1056/NEJM199209033271010. [DOI] [PubMed] [Google Scholar]
- Erhardt L., MacLean A., Ilgenfritz J., Gelperin K., Blumenthal M. Fosinopril attenuates clinical deterioration and improves exercise tolerance in patients with heart failure. Fosinopril Efficacy/Safety Trial (FEST) Study Group. Eur Heart J. 1995 Dec;16(12):1892–1899. doi: 10.1093/oxfordjournals.eurheartj.a060844. [DOI] [PubMed] [Google Scholar]
- Feinstein A. R., Fisher M. B., Pigeon J. G. Changes in dyspnea-fatigue ratings as indicators of quality of life in the treatment of congestive heart failure. Am J Cardiol. 1989 Jul 1;64(1):50–55. doi: 10.1016/0002-9149(89)90652-8. [DOI] [PubMed] [Google Scholar]
- Grinstead W. C., Francis M. J., Marks G. F., Tawa C. B., Zoghbi W. A., Young J. B. Discontinuation of chronic diuretic therapy in stable congestive heart failure secondary to coronary artery disease or to idiopathic dilated cardiomyopathy. Am J Cardiol. 1994 May 1;73(12):881–886. doi: 10.1016/0002-9149(94)90815-x. [DOI] [PubMed] [Google Scholar]
- Henwood J. M., Todd P. A. Ibopamine. A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1988 Jul;36(1):11–31. doi: 10.2165/00003495-198836010-00003. [DOI] [PubMed] [Google Scholar]
- Kleber F. X., Thyroff-Friesinger U. Ibopamine versus digoxin in the treatment of mild congestive heart failure. A double-blind, randomized, placebo-controlled trial. Cardiology. 1990;77 (Suppl 5):75–80. doi: 10.1159/000174700. [DOI] [PubMed] [Google Scholar]
- Parker J. O. The effects of oral ibopamine in patients with mild heart failure--a double blind placebo controlled comparison to furosemide. The Ibopamine Study Group. Int J Cardiol. 1993 Jul 15;40(3):221–227. doi: 10.1016/0167-5273(93)90004-z. [DOI] [PubMed] [Google Scholar]
- Pfeffer M. A., Braunwald E., Moyé L. A., Basta L., Brown E. J., Jr, Cuddy T. E., Davis B. R., Geltman E. M., Goldman S., Flaker G. C. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992 Sep 3;327(10):669–677. doi: 10.1056/NEJM199209033271001. [DOI] [PubMed] [Google Scholar]
- Rousseau M. F., Raigoso J., van Eyll C., Van Mechelen H., Musso N. R., Lotti G., Pouleur H. Effects of intravenous epinine administration on left ventricular systolic performance, coronary hemodynamics, and circulating catecholamines in patients with heart failure. J Cardiovasc Pharmacol. 1992 Feb;19(2):155–162. doi: 10.1097/00005344-199202000-00001. [DOI] [PubMed] [Google Scholar]
- van Veldhuisen D. J., Brouwer J., Man in 't Veld A. J., Dunselman P. H., Boomsma F., Lie K. I. Progression of mild untreated heart failure during six months follow-up and clinical and neurohumoral effects of ibopamine and digoxin as monotherapy. DIMT Study Group. Dutch Ibopamine Multicenter Trial. Am J Cardiol. 1995 Apr 15;75(12):796–800. doi: 10.1016/s0002-9149(99)80414-7. [DOI] [PubMed] [Google Scholar]
- van Veldhuisen D. J., Man in 't Veld A. J., Dunselman P. H., Lok D. J., Dohmen H. J., Poortermans J. C., Withagen A. J., Pasteuning W. H., Brouwer J., Lie K. I. Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT). J Am Coll Cardiol. 1993 Nov 15;22(6):1564–1573. doi: 10.1016/0735-1097(93)90579-p. [DOI] [PubMed] [Google Scholar]