Table 1. α-catulin-GFP+ cells were highly enriched for long-term multilineage reconstituting HSCs.
Donor cell population | Donor cell dose | LTMR mice | HSC frequency |
---|---|---|---|
Unfractionated bone marrow | 25,000 | 19/27 | 1/37,000 |
50,000 | 15/25 | ||
100,000 | 21/23 | ||
300,000 | 14/14 | ||
| |||
α-catulin-GFP+ | 1 | 2/13 | 1/6.7 |
5 | 13/25 | ||
| |||
α-catulin-GFP− | 300,000 | 2/20 | 1/2,847,000 |
| |||
α-catulin-GFP+c-kit+ | 1 | 9/34 | 1/3.5 |
5 | 17/23 | ||
30 | 14/14 | ||
| |||
α-catulin-GFP−CD150+CD48−Lin−c-kit+Sca1+ | 5 | 2/44 | 1/110 |
| |||
α-catulin-GFP+CD150+CD48−Lin−c-kit+Sca1+ | 5 | 24/30 | 1/3.1 |