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. 2015 Oct 13;36(12):1580–1589. doi: 10.1093/carcin/bgv148

Figure 2.

Figure 2.

ABPN triggers apoptosis. (A) Treatment of cells with ABPN increases the subG1 fraction. BxPC3 cells were treated with ABPN, ATRA or erlotinib as indicated and cell cycle was analyzed using flow cytometry. All data are presented as mean values ± SD (in triplicate). (B) ABPN induces cleavage of caspase-3 and PARP in BxPC3 and HPAC cells. (C) Differential effects of ABPN on PARP cleavage. (D) Expression of ErbB3, Met, EGFR, ErbB2 in BxPC3, HPAC, Panc-1 and Mia Paca-2 cancer cells. β-Actin served as a loading control and immunoblots are representative images of three independent experiments (one-way ANOVA and Dunnett’s test. NS, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, significant differences between DMSO-treated control and drug-treated groups). All data are presented as mean values ± SD (in triplicate).