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. 1994 Oct;57(10):1191–1194. doi: 10.1136/jnnp.57.10.1191

No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs.

N W Wood 1, P Holmans 1, D Clayton 1, N Robertson 1, D A Compston 1
PMCID: PMC485485  PMID: 7523603

Abstract

Myelin basic protein was examined as a candidate gene for susceptibility to multiple sclerosis using two adjacent amplification fragment length polymorphisms (AmpFLPs), containing seven and six highly informative alleles respectively. No allelic association was found with multiple sclerosis, comparing 77 cases and 88 controls, and there was no evidence for linkage in 73 affected sibling pairs, using the methods of identity by descent and identity by state.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altmann D. M., Sansom D., Marsh S. G. What is the basis for HLA-DQ associations with autoimmune disease? Immunol Today. 1991 Aug;12(8):267–270. doi: 10.1016/0167-5699(91)90124-C. [DOI] [PubMed] [Google Scholar]
  2. Beall S. S., Concannon P., Charmley P., McFarland H. F., Gatti R. A., Hood L. E., McFarlin D. E., Biddison W. E. The germline repertoire of T cell receptor beta-chain genes in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1989 Jan;21(1):59–66. doi: 10.1016/0165-5728(89)90159-8. [DOI] [PubMed] [Google Scholar]
  3. Boylan K. B., Takahashi N., Paty D. W., Sadovnick A. D., Diamond M., Hood L. E., Prusiner S. B. DNA length polymorphism 5' to the myelin basic protein gene is associated with multiple sclerosis. Ann Neurol. 1990 Mar;27(3):291–297. doi: 10.1002/ana.410270311. [DOI] [PubMed] [Google Scholar]
  4. Charmley P., Beall S. S., Concannon P., Hood L., Gatti R. A. Further localization of a multiple sclerosis susceptibility gene on chromosome 7q using a new T cell receptor beta-chain DNA polymorphism. J Neuroimmunol. 1991 Jun;32(3):231–240. doi: 10.1016/0165-5728(91)90193-b. [DOI] [PubMed] [Google Scholar]
  5. Charmley P., Chao A., Concannon P., Hood L., Gatti R. A. Haplotyping the human T-cell receptor beta-chain gene complex by use of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4823–4827. doi: 10.1073/pnas.87.12.4823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ebers G. C., Bulman D. E., Sadovnick A. D., Paty D. W., Warren S., Hader W., Murray T. J., Seland T. P., Duquette P., Grey T. A population-based study of multiple sclerosis in twins. N Engl J Med. 1986 Dec 25;315(26):1638–1642. doi: 10.1056/NEJM198612253152603. [DOI] [PubMed] [Google Scholar]
  7. Ebers G. C., Paty D. W., Stiller C. R., Nelson R. F., Seland T. P., Larsen B. HLA-typing in multiple sclerosis sibling pairs. Lancet. 1982 Jul 10;2(8289):88–90. doi: 10.1016/s0140-6736(82)91702-0. [DOI] [PubMed] [Google Scholar]
  8. Graham C. A., Kirk C. W., Nevin N. C., Droogan A. G., Hawkins S. A., McMillan S. A., McNeill T. A. Lack of association between myelin basic protein gene microsatellite and multiple sclerosis. Lancet. 1993 Jun 19;341(8860):1596–1596. doi: 10.1016/0140-6736(93)90734-x. [DOI] [PubMed] [Google Scholar]
  9. Hashimoto L. L., Mak T. W., Ebers G. C. T cell receptor alpha chain polymorphisms in multiple sclerosis. J Neuroimmunol. 1992 Sep;40(1):41–48. doi: 10.1016/0165-5728(92)90211-3. [DOI] [PubMed] [Google Scholar]
  10. Hashimoto L. L., Walter M. A., Cox D. W., Ebers G. C. Immunoglobulin heavy chain variable region polymorphisms and multiple sclerosis susceptibility. J Neuroimmunol. 1993 Apr;44(1):77–83. doi: 10.1016/0165-5728(93)90270-9. [DOI] [PubMed] [Google Scholar]
  11. Hillert J., Leng C., Olerup O. T-cell receptor alpha chain germline gene polymorphisms in multiple sclerosis. Neurology. 1992 Jan;42(1):80–84. doi: 10.1212/wnl.42.1.80. [DOI] [PubMed] [Google Scholar]
  12. Hillert J., Olerup O. Germ-line polymorphism of TCR genes and disease susceptibility--fact or hypothesis? Immunol Today. 1992 Feb;13(2):47–49. doi: 10.1016/0167-5699(92)90132-Q. [DOI] [PubMed] [Google Scholar]
  13. Holmans P. Asymptotic properties of affected-sib-pair linkage analysis. Am J Hum Genet. 1993 Feb;52(2):362–374. [PMC free article] [PubMed] [Google Scholar]
  14. Jersild C., Svejgaard A., Fog T. HL-A antigens and multiple sclerosis. Lancet. 1972 Jun 3;1(7762):1240–1241. doi: 10.1016/s0140-6736(72)90962-2. [DOI] [PubMed] [Google Scholar]
  15. Kamholz J., Spielman R., Gogolin K., Modi W., O'Brien S., Lazzarini R. The human myelin-basic-protein gene: chromosomal localization and RFLP analysis. Am J Hum Genet. 1987 Apr;40(4):365–373. [PMC free article] [PubMed] [Google Scholar]
  16. Kamholz J., de Ferra F., Puckett C., Lazzarini R. Identification of three forms of human myelin basic protein by cDNA cloning. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4962–4966. doi: 10.1073/pnas.83.13.4962. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Kirschner D. A., Ganser A. L. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse. Nature. 1980 Jan 10;283(5743):207–210. doi: 10.1038/283207a0. [DOI] [PubMed] [Google Scholar]
  18. Lange K. The affected sib-pair method using identity by state relations. Am J Hum Genet. 1986 Jul;39(1):148–150. [PMC free article] [PubMed] [Google Scholar]
  19. McFarland H. F. Twin studies and multiple sclerosis. Ann Neurol. 1992 Dec;32(6):722–723. doi: 10.1002/ana.410320603. [DOI] [PubMed] [Google Scholar]
  20. Mumford C. J., Wood N. W., Kellar-Wood H., Thorpe J. W., Miller D. H., Compston D. A. The British Isles survey of multiple sclerosis in twins. Neurology. 1994 Jan;44(1):11–15. doi: 10.1212/wnl.44.1.11. [DOI] [PubMed] [Google Scholar]
  21. Oksenberg J. R., Sherritt M., Begovich A. B., Erlich H. A., Bernard C. C., Cavalli-Sforza L. L., Steinman L. T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis. Proc Natl Acad Sci U S A. 1989 Feb;86(3):988–992. doi: 10.1073/pnas.86.3.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Olerup O., Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens. 1991 Jul;38(1):1–15. doi: 10.1111/j.1399-0039.1991.tb02029.x. [DOI] [PubMed] [Google Scholar]
  23. Omlin F. X., Webster H. D., Palkovits C. G., Cohen S. R. Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin. J Cell Biol. 1982 Oct;95(1):242–248. doi: 10.1083/jcb.95.1.242. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Pette M., Fujita K., Wilkinson D., Altmann D. M., Trowsdale J., Giegerich G., Hinkkanen A., Epplen J. T., Kappos L., Wekerle H. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7968–7972. doi: 10.1073/pnas.87.20.7968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Polymeropoulos M. H., Xiao H., Merril C. R. Tetranucleotide repeat polymorphism at the human myelin basic protein gene (MBP). Hum Mol Genet. 1992 Nov;1(8):658–658. doi: 10.1093/hmg/1.8.658. [DOI] [PubMed] [Google Scholar]
  26. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  27. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet. 1990 Feb;46(2):229–241. [PMC free article] [PubMed] [Google Scholar]
  28. Risch N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet. 1990 Feb;46(2):242–253. [PMC free article] [PubMed] [Google Scholar]
  29. Rose J., Gerken S., Lynch S., Pisani P., Varvil T., Otterud B., Leppert M. Genetic susceptibility in familial multiple sclerosis not linked to the myelin basic protein gene. Lancet. 1993 May 8;341(8854):1179–1181. doi: 10.1016/0140-6736(93)91003-5. [DOI] [PubMed] [Google Scholar]
  30. Sadovnick A. D., Armstrong H., Rice G. P., Bulman D., Hashimoto L., Paty D. W., Hashimoto S. A., Warren S., Hader W., Murray T. J. A population-based study of multiple sclerosis in twins: update. Ann Neurol. 1993 Mar;33(3):281–285. doi: 10.1002/ana.410330309. [DOI] [PubMed] [Google Scholar]
  31. Sadovnick A. D., Baird P. A. The familial nature of multiple sclerosis: age-corrected empiric recurrence risks for children and siblings of patients. Neurology. 1988 Jun;38(6):990–991. doi: 10.1212/wnl.38.6.990. [DOI] [PubMed] [Google Scholar]
  32. Seboun E., Robinson M. A., Doolittle T. H., Ciulla T. A., Kindt T. J., Hauser S. L. A susceptibility locus for multiple sclerosis is linked to the T cell receptor beta chain complex. Cell. 1989 Jun 30;57(7):1095–1100. doi: 10.1016/0092-8674(89)90046-9. [DOI] [PubMed] [Google Scholar]
  33. Steinman L. Multiple sclerosis and its animal models: the role of the major histocompatibility complex and the T cell receptor repertoire. Springer Semin Immunopathol. 1992;14(1):79–93. doi: 10.1007/BF00197133. [DOI] [PubMed] [Google Scholar]
  34. Steinman L., Oksenberg J. R., Bernard C. C. Association of susceptibility to multiple sclerosis with TCR genes. Immunol Today. 1992 Feb;13(2):49–51. doi: 10.1016/0167-5699(92)90133-R. [DOI] [PubMed] [Google Scholar]
  35. Tienari P. J., Wikström J., Sajantila A., Palo J., Peltonen L. Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene. Lancet. 1992 Oct 24;340(8826):987–991. doi: 10.1016/0140-6736(92)93007-a. [DOI] [PubMed] [Google Scholar]
  36. Walter M. A., Gibson W. T., Ebers G. C., Cox D. W. Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region. J Clin Invest. 1991 Apr;87(4):1266–1273. doi: 10.1172/JCI115128. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Wraith D. C., Smilek D. E., Mitchell D. J., Steinman L., McDevitt H. O. Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. Cell. 1989 Oct 20;59(2):247–255. doi: 10.1016/0092-8674(89)90287-0. [DOI] [PubMed] [Google Scholar]

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